TABLE 3.
MICs of β-lactams for seven clinical isolates of L. hongkongensis, E. coli XLOLR harboring recombinant plasmid pBK-LHK-5, and E. coli XLOLR
| Bacterial strain | MIC (μg/ml)b
|
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AMP | AMP-CA | AMP-SBM | FOX | CXM | CAZ | CTX | CPZ | CPZ-SBM | FEP | ATM | IPM | MPM | |
| L. hongkongensis | |||||||||||||
| HKU1 | 32 | 32 | 16 | 16 | 16 | >256 | 64 | >256 | >256 | 64 | >256 | 0.0625 | 0.0625 |
| HLHK2 | 128 | 128 | 64 | 128 | 256 | >256 | >256 | >256 | >256 | >256 | >256 | 0.0625 | 0.0625 |
| HLHK3 | 256 | 256 | 64 | 64 | 32 | >256 | 128 | >256 | >256 | 32 | >256 | 0.0625 | 0.03125 |
| HLHK4 | 256 | 256 | 128 | 128 | 64 | >256 | 256 | >256 | >256 | >256 | >256 | 0.0625 | 0.0625 |
| HLHK5 | 256 | 64 | 128 | 64 | 64 | >256 | 256 | >256 | >256 | 128 | >256 | 0.0625 | 0.0625 |
| HLHK6 | 256 | 256 | 128 | 64 | 16 | 256 | 128 | >256 | >256 | 128 | >256 | 0.125 | 0.0625 |
| HLHK7 | 64 | 64 | 64 | 64 | 32 | 128 | 128 | >256 | >256 | 2 | >256 | 0.0625 | 0.0625 |
| E. coli | |||||||||||||
| XLOLR(pBK-LHK-5)a | 64 | 64 | 32 | 16 | 128 | 64 | 32 | >256 | >256 | 32 | >256 | 0.125 | 0.0625 |
| XLOLR | 8 | 4 | 4 | 16 | 32 | 4 | 8 | 8 | 8 | 8 | 128 | 0.125 | 0.0625 |
a
This strain, which harbors the recombinant plasmid pBK-LHK-5, produced the LHK-5 β-lactamase.
b
AMP, ampicillin; AMP-CA, ampicillin plus clavulanic acid (2 μg/ml); AMP-SBM, ampicillin plus sulbactam (4 μg/ml); FOX, cefoxitin; CXM, cefuroxime; CAZ, ceftazidime; CTX, cefotaxime; CPZ, cefoperazone; CPZ-SBM, cefoperazone plus sulbactam (4 μg/ml); FEP, cefepime; ATM, aztreonam; IPM, imipenem; MPM, meropenem.