TABLE 2.
Drug | Total amt recoveredb (μg-eq)
|
||
---|---|---|---|
Plasma | PBMC | RBC | |
GS 7340 | 43.0 ± 7.8 | 1.25 ± 0.22 | 12.6 ± 3.02 |
Tenofovir DF | 48.10 ± 8.7 | 0.133 ± 0.029 | 10.5 ± 5.17 |
Tenofovir | 55.70 ± 4.5 | 0.033 ± 0.014 | 3.72 ± 1.86 |
A total of 10 μg-eq/ml of 14C-labeled compound was incubated for 1 h at 37°C in human blood, followed by Ficoll-Paque separation of the blood fractions.
Mean±SD, n = 3.