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. 2005 May;49(5):1898–1906. doi: 10.1128/AAC.49.5.1898-1906.2005

TABLE 2.

Distribution of all tenofovir-related species after incubation of 14C-labeled drug in human whole blooda

Drug Total amt recoveredb (μg-eq)
Plasma PBMC RBC
GS 7340 43.0 ± 7.8 1.25 ± 0.22 12.6 ± 3.02
Tenofovir DF 48.10 ± 8.7 0.133 ± 0.029 10.5 ± 5.17
Tenofovir 55.70 ± 4.5 0.033 ± 0.014 3.72 ± 1.86
a

A total of 10 μg-eq/ml of 14C-labeled compound was incubated for 1 h at 37°C in human blood, followed by Ficoll-Paque separation of the blood fractions.

b

Mean±SD, n = 3.