TABLE 4.
Pharmacokinetics of tenofovir in plasma after oral administration of GS 7340, GS 7339, and GS 7171 in fasted dogsa
| Drug (route) | AUC0-24 (μg · h/ml) | Cmax (μg/ml) | Tmax (h) | t1/2 (h) | %Fd |
|---|---|---|---|---|---|
| GS 7340 (p.o.)b | 7.88 (2.24) | 0.82 (0.17) | 1.0 (0.0) | 23.2 (12.9) | 16.9 (4.8) |
| GS 7339 (p.o.)b | 6.14 (2.06) | 0.94 (0.21) | 1.25 (0.5) | 10.4 (2.2) | 13.1 (4.4) |
| GS 7171 (p.o.)c | 8.17 (1.2) | 0.91 (0.21) | 0.94 (0.79) | 20 (4) | 19.7 (2.8) |
a
Data are means±SD for groups of five dogs. p.o., oral.
b
Dose as tenofovir(mg-eq/kg) = 10.85.
c
Dose as tenofovir(mg-eq/kg) = 9.64.
d
%F calculated from AUC0-∞ = 4.30 μg-h/ml for a 1-mg/kg dose of intravenous tenofovir.