FIG. 3.

Localization of novel mutations in the structure of HIV-1 protease. (A) A ribbon model of HIV-1 protease showing the three different classes of novel mutations and all mutations correlated. (B) Insights into the protease molecular surface showing changes in charge distribution due to mutations D30N, K45R, and N88D. Red and blue, negatively and positively charged regions, respectively. In panel 2 side chains of mutated residues are rotated to minimize strong van der Waals clashes. (C) Hydrogen bond networks among residues at positions 90, 93, 94, and 95. Grey, carbonium atoms; red, oxygen atoms; blue, nitrogen atoms; yellow, the sulfur atom of Cys.