TABLE 2.
Combination index and dose reduction values for inhibition of infection by a primary HIV-1 isolate 92US657 of PBMCa
% Inhibition | CI | CAP
|
UC781
|
||||||
---|---|---|---|---|---|---|---|---|---|
Concn (μg/ml)
|
Dose reduction | P | Concn (μg/ml)
|
Dose reduction | P | ||||
Alone | Mix | Alone | Mix | ||||||
50 | 0.3878 | 29.823 | 5.480 | 5.442 | 0.0016 | 0.00772 | 0.00274 | 2.821 | 0.0034 |
70 | 0.4161 | 45.119 | 7.565 | 5.964 | 0.00036 | 0.00921 | 0.00378 | 2.435 | 0.0043 |
90 | 0.4761 | 87.260 | 12.648 | 6.899 | 0.00001 | 0.01219 | 0.00633 | 1.927 | 0.0069 |
95 | 0.5182 | 125.712 | 16.809 | 7.479 | 0.00017 | 0.01422 | 0.00845 | 1.692 | 0.0108 |
Combinations of CAP with UC781 (2,000:1 [wt/wt]) were used. Data are the means of triplicate experiments.