Table 2.
Association between TSH normalization and characteristics in older adults with subclinical hypothyroidism from the pretrial population (N = 2335)
| Characteristic | Univariable model | Multivariable model | ||
|---|---|---|---|---|
| OR (95% CI) | P | OR (95% CI) | P | |
| Age (per year) | .98 (.97-.99) | <.001 | .98 (.97-.99) | .007 |
| Female sex | 1.39 (1.16-1.66) | <.001 | 1.39 (1.15-1.69) | <.001 |
| TSH level (per unit mIU/L) | .56 (.52-.61) | <.001 | .57 (.52-.62) | <.001 |
| fT4 level (per unit pmol/L) | 1.08 (1.04-1.13) | <.001 | 1.06 (1.01-1.11) | .03 |
| Interval between measurements | ||||
| <6 mo | 1 (reference) | 1 (reference) | ||
| 6-12 mo | 1.05 (.81-1.35) | .73 | 1.02 (.78-1.34) | .87 |
| >12 mo | 1.40 (1.07-1.82) | .01 | 1.30 (.97-1.72) | .07 |
| Season second measurement | ||||
| Summer | 1 (reference) | 1 (reference) | ||
| Autumn | .74 (.59-.93) | .008 | .72 (.57-.92) | .008 |
| Winter | .62 (.47-.82) | <.001 | .59 (.44-.79) | <.001 |
| Spring | .73 (.57-.92) | .009 | .73 (.56-.95) | .02 |
Odds ratios (OR) with 95% CIs resulting from logistic regression analyses. Univariable models were created for each characteristic separately and multivariable models were created with all characteristics combined. All analyses were adjusted for country.
Abbreviation: OR, odds ratio.