Table 4.

Association between TSH normalization and characteristics in older adults with persistent subclinical hypothyroidism from the in-trial placebo group (N = 361)

Characteristic	Univariable model		Multivariable model
	OR (95% CI)	P	OR (95% CI)	P
Age (per year)	.99 (.96-1.02)	.59	.96 (.92-1.00)	.05
Female sex	1.23 (.79-1.92)	.36	1.80 (1.01-3.23)	.05
TSH level at trial baseline (per unit mIU/L)	.51 (.40-.63)	<.001	.52 (.38-.67)	<.001
fT4 level at trial baseline (per unit pmol/L)	1.32 (1.17-1.50)	<.001	1.22 (1.05-1.44)	.01
Anti-TPO positivity×	.38 (.19-.72)	.004	.36 (.17-.77)	.007

Odds ratios (OR) with 95% CIs resulting from logistic regression analyses. Univariable models were created for each characteristic separately and multivariable models were created with all characteristics combined. All analyses were adjusted for country. ^×Information on TPO antibodies was missing for n = 72.

Abbreviation: anti-TPO, thyroid peroxidase antibodies.