Table 4. Multiple logistic regression analysis of impaired lung function by quartile of apolipoprotein B/apolipoprotein A-I ratio.
| Characteristics | Model 1 | Model 2 | Model 3 | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | P value | P for trend | OR (95% CI) | P value | P for trend | OR (95% CI) | P value | P for trend | ||
| FEV1% < LLN | < 0.001 | < 0.001 | < 0.001 | |||||||
| Q1 (≤ 0.5135) (reference) | 1.000 | 1.000 | 1.000 | |||||||
| Q2 (0.5136–0.6444) | 1.229 (1.109–1.361) | < 0.001 | 1.220 (1.099–1.355) | < 0.001 | 1.216 (1.094–1.351) | < 0.001 | ||||
| Q3 (0.6445–0.8050) | 1.326 (1.190–1.476) | < 0.001 | 1.305 (1.167–1.460) | < 0.001 | 1.293 (1.156–1.448) | < 0.001 | ||||
| Q4 (≥ 0.8051) | 1.507 (1.343–1.691) | < 0.001 | 1.488 (1.319–1.679) | < 0.001 | 1.481 (1.311–1.672) | < 0.001 | ||||
| FVC% < LLN | < 0.001 | < 0.001 | < 0.001 | |||||||
| Q1 (≤ 0.5135) (reference) | 1.000 | 1.000 | 1.000 | |||||||
| Q2 (0.5136–0.6444) | 1.263 (1.139–1.400) | < 0.001 | 1.225 (1.102–1.362) | < 0.001 | 1.212 (1.090–1.348) | < 0.001 | ||||
| Q3 (0.6445–0.8050) | 1.367 (1.228–1.522) | < 0.001 | 1.303 (1.165–1.458) | < 0.001 | 1.283 (1.147–1.436) | < 0.001 | ||||
| Q4 (≥ 0.8051) | 1.603 (1.431–1.796) | < 0.001 | 1.520 (1.349–1.713) | <0.001 | 1.502 (1.331–1.695) | < 0.001 | ||||
| FEV1(L)/FVC(L) ratio < LLN | 0.154 | 0.203 | 0.273 | |||||||
| Q1 (≤ 0.5135) (reference) | 1.000 | 1.000 | 1.000 | |||||||
| Q2 (0.5136–0.6444) | 1.026 (0.773–1.363) | 0.857 | 1.030 (0.769–1.381) | 0.841 | 1.005 (0.745–1.355) | 0.975 | ||||
| Q3 (0.6445–0.8050) | 1.174 (0.824–1.673) | 0.373 | 1.164 (0.804–1.685) | 0.422 | 1.122 (0.769–1.636) | 0.551 | ||||
| Q4 (≥ 0.8051) | 1.393 (0.997–1.947) | 0.052 | 1.376 (0.971–1.949) | 0.072 | 1.357 (0.952–1.935) | 0.092 | ||||
Model 1 was adjusted for age, sex, body mass index, smoking status, heavy alcohol intake, regular exercise, and education level. Model 2 was adjusted as in Model 1 plus for metabolic components including MBP, glucose, hemoglobin A1c, homeostasis model assessment of insulin resistance, total cholesterol, triglycerides, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol. Model 3 was adjusted as in Model 2 plus high-sensitivity C-reactive protein and variables with a P value < 0.05 in the univariate analyses.
MBP = Diastolic Blood Pressure (Average Systolic Blood Pressure − Average Diastolic Blood Pressure)/3.
FEV1% = percent predicted forced expiratory volume in 1 second, FVC% = percent predicted forced vital capacity, LLN = lower limit of normal, FEV1 = forced expiratory volume in 1 second, FVC = forced vital capacity, MBP = mean blood pressure.