FIG. 2.

Replication fitness of chimeric genotype 1a and 1b replicons encoding patient NS5B isolates. Replication was measured as described in Materials and Methods, and replication levels were normalized to that of con1. The genotype of NS5B is indicated by color: blue for genotype 1a and green for genotype 1b. Solid bars represent a genotypically homologous replicon between the replicon backbone (NS3-5A) and NS5B. Hatched bars indicate a genotypically heterologous replicon between NS5B and the replicon backbone, with the color of the hatched bars representing the genotype of the polymerase.