FIG. 6.

Variability among NS5B isolates from infected chimpanzee serum. The complete sequences of multiple NS5B isolates from infected chimpanzees were determined. Positions which differ from those in the prototype sequences are shown. cs2a con is the consensus sequence generated among our rescued genotype 2a sequences. The boxed residues in the genotype 4a and genotype 6a alignments are the positions within con1 that conferred resistance to the nucleoside inhibitor 2′C-methyladenosine and the nonnucleoside benzimidazole inhibitor NNI 1, respectively.