TABLE 1.

Clinical NS5B isolates support subgenomic replication

^aThe result for the designated genotype is in boldface.

^bReplication fitness was determined by direct comparison of A₄₆₀ values to those for con1 replicons, which were normalized to a relative fitness of 1, as described in Materials and Methods. All experiments were performed in triplicate, and the values are means ± standard deviations.