Table 2.
Characteristics of the 30 proteins selected for further analysis. Note that centered (by the median) and scaled (by the interquartile range) protein levels are used in the computations (see Methods).
| Protein | Preoperative levels | Postoperative levels | Perioperative change | p value | Protein name | Protein description | KEGG pathway database classification | Specification of organismal systems |
|---|---|---|---|---|---|---|---|---|
| Median [IQR] | Median [IQR] | Median [IQR] | (adjusted p) | |||||
| ACTA1 | −0.29 [−0.57 to 0.07] | 0.47 [−0.03 to 0.89] | 0.57 [0.10 to 1.18] | <0.001 (<0.001) | ACTS_HUMAN | Actin, alpha skeletal muscle | 4 | |
| ACTB;ACTG1 | −0.42 [−0.69 to −0.10] | 0.50 [0.12 to 1.04] | 0.93 [0.48 to 1.44] | <0.001 (<0.001) | ACTB_HUMAN; ACTG_HUMAN | Actin, cytoplasmic 1 | 5 | Immune system, endocrine system, digestive system, environmental adaptation |
| AGT | −0.44 [−0.68 to −0.15] | 0.45 [0.10 to 0.78] | 0.86 [0.57 to 1.18] | <0.001 (<0.001) | ANGT_HUMAN | Angiotensinogen | 3; 5 | Endocrine, circulatory |
| ALDOA | −0.45 [−0.67 to −0.13] | 0.44 [0.09 to 0.85] | 0.85 [0.51 to 1.30] | <0.001 (<0.001) | ALDOA_HUMAN | Fructose-bisphosphate aldolase A | 1; 3 | |
| C1S | −0.24 [−0.65 to 0.16] | 0.28 [−0.19 to 0.74] | 0.58 [−0.03 to 1.09] | <0.001 (<0.001) | C1S_HUMAN | Complement C1s subcomponent | 5 | Immune |
| CAT | −0.43 [−0.70 to −0.01] | 0.34 [0.00 to 0.92] | 0.81 [0.19 to 1.41] | <0.001 (<0.001) | CATA_HUMAN | Catalase | 1; 3; 4; 5 | Aging |
| CD14 | −0.41 [−0.64 to −0.15] | 0.57 [0.18 to 1.01] | 0.95 [0.60 to 1.31] | <0.001 (<0.001) | CD14_HUMAN | Monocyte differentiation antigen CD14 | 3; 4; 5 | Immune |
| CRP | −0.39 [−0.40 to −0.36] | 0.61 [0.36 to 0.92] | 0.99 [0.71 to 1.28] | <0.001 (<0.001) | CRP_HUMAN | C-reactive protein | no KO | |
| CST3 | −0.23 [−0.70 to 0.19] | 0.22 [−0.18 to 0.92] | 0.62 [0.10 to 1.18] | <0.001 (<0.001) | CYTC_HUMAN | Cystatin-C | 5 | Digestive |
| GAPDH | −0.28 [−0.71 to 0.27] | 0.25 [−0.19 to 0.70] | 0.60 [−0.09 to 1.06] | <0.001 (<0.001) | G3P_HUMAN | Glyceraldehyde-3-phosphate dehydrogenase | 1; 3 | |
| GSTO1 | −0.31 [−0.61 to 0.00] | 0.54 [0.00 to 1.17] | 0.86 [0.35 to 1.29] | <0.001 (<0.001) | GSTO1_HUMAN | Glutathione S-transferase omega-1 | 1 | |
| IGFBP2 | −0.29 [−0.49 to 0.00] | 0.50 [0.00 to 1.08] | 0.72 [0.38 to 1.37] | <0.001 (<0.001) | IBP2_HUMAN | Insulin-like growth factor-binding protein 2 | 2 | |
| LBP | −0.35 [−0.43 to −0.27] | 0.65 [0.41 to 0.93] | 0.96 [0.75 to 1.24] | <0.001 (<0.001) | LBP_HUMAN | Lipopolysaccharide-binding protein | 3; 5 | Immune |
| LCP1 | −0.40 [−0.75 to 0.00] | 0.43 [0.00 to 0.73] | 0.72 [0.30 to 1.22] | <0.001 (<0.001) | PLSL_HUMAN | Plastin-2 | 4 | |
| LDHB | −0.33 [−0.49 to −0.15] | 0.66 [0.20 to 1.21] | 0.97 [0.60 to 1.43] | <0.001 (<0.001) | LDHB_HUMAN | L-lactate dehydrogenase B chain | 1; 3; 5 | Endocrine |
| LRG1 | −0.43 [−0.54 to −0.29] | 0.52 [0.25 to 0.90] | 0.91 [0.66 to 1.23] | <0.001 (<0.001) | A2GL_HUMAN | Leucine-rich alpha-2-glycoprotein | no KO | |
| MAN1A1 | −0.42 [−0.64 to −0.24] | 0.56 [0.27 to 0.90] | 0.99 [0.68 to 1.31] | <0.001 (<0.001) | MA1A1_HUMAN | Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA | 1; 2 | |
| PCSK9 | −0.25 [−0.63 to 0.23] | 0.28 [−0.16 to 0.83] | 0.51 [−0.09 to 1.03] | <0.001 (<0.001) | PCSK9_HUMAN | Proprotein convertase subtilisin/kexin type 9 | 5 | Digestive |
| PDE4DIP | −0.33 [−0.53 to 0.04] | 0.41 [−0.03 to 0.91] | 0.64 [0.16 to 1.18] | <0.001 (<0.001) | MYOME_HUMAN | Myomegalin | 2 | |
| PFN1 | −0.40 [−0.67 to 0.07] | 0.31 [−0.09 to 0.79] | 0.69 [0.28 to 1.19] | <0.001 (<0.001) | PROF1_HUMAN | Profilin-1 | 3; 4 | |
| S100A8 | −0.39 [−0.58 to −0.14] | 0.55 [0.17 to 1.16] | 0.92 [0.56 to 1.45] | <0.001 (<0.001) | S10A8_HUMAN | Protein S100-A8 | 5 | Immune |
| SAA1 | −0.27 [−0.27 to −0.25] | 0.73 [0.40 to 0.96] | 0.95 [0.62 to 1.20] | <0.001 (<0.001) | SAA1_HUMAN | Serum amyloid A-1 protein | 4 | |
| SAA4 | −0.33 [−0.61 to 0.03] | 0.43 [−0.06 to 0.85] | 0.74 [0.27 to 1.21] | <0.001 (<0.001) | SAA4_HUMAN | Serum amyloid A-4 protein | 4 | |
| SERPINA1 | −0.47 [−0.64 to −0.24] | 0.52 [0.26 to 0.74] | 0.91 [0.65 to 1.18] | <0.001 (<0.001) | A1AT_HUMAN | Alpha-1-antitrypsin | 5 | Immune |
| SERPINA10 | −0.47 [−0.66 to −0.23] | 0.52 [0.22 to 0.77] | 0.86 [0.68 to 1.18] | <0.001 (<0.001) | ZPI_HUMAN | Protein Z-dependent protease inhibitor | 1 | |
| SERPINA3 | −0.51 [−0.60 to −0.37] | 0.49 [0.29 to 0.74] | 1.00 [0.74 to 1.25] | <0.001 (<0.001) | AACT_HUMAN | Alpha-1-antichymotrypsin | 5 | Immune (complement and coagulation) |
| SERPINA5 | 0.58 [0.22 to 0.92] | −0.35 [−0.59 to −0.11] | −0.92 [−1.20 to −0.60] | <0.001 (<0.001) | IPSP_HUMAN | Plasma serine protease inhibitor | 5 | Immune (complement and coagulation) |
| SPP2 | 0.47 [−0.07 to 0.96] | −0.26 [−0.54 to 0.06] | −0.68 [−1.16 to −0.23] | <0.001 (<0.001) | SPP24_HUMAN | Secreted phosphoprotein 24 | no KO | |
| VCAM1 | −0.24 [−0.69 to 0.10] | 0.38 [−0.15 to 0.99] | 0.65 [0.19 to 1.24] | <0.001 (<0.001) | VCAM1_HUMAN | Vascular cell adhesion protein 1 | 3; 5 | Immune |
| VCL | −0.37 [−0.64 to −0.02] | 0.51 [0.02 to 1.11] | 0.94 [0.47 to 1.46] | <0.001 (<0.001) | VINC_HUMAN | Vinculin | 4; 5 | Immune |