Table 3.
Adjusted associations of preoperative protein levels with postoperative outcome. Odds ratios (ORs) and 95%-confidence intervals derived from a multivariable linear regression are shown for binary outcomes, whereas regression coefficient and their 95%-confidence intervals computed with a multivariable linear regression are shown for the continuous outcome length of hospital stay. The associations are adjusted for age, gender and BMI. P-values are adjusted for multiple comparison for each outcome separately by means of the Bonferroni correction.
| Protein | Stroke | Myocardial infarction | 1-year mortality | Length of stay | ||||
|---|---|---|---|---|---|---|---|---|
| Incidence 12/192 (6.3%) | Incidence 6/192 (3.1%) | Incidence 5/192 (2.6%) | Median 7 [IQR: 6–9 ] days | |||||
| OR (95%-CI) | p (adjusted p) | OR (95%-CI) | p (adjusted p) | OR (95%-CI) | p (adjusted p) | Beta (95%-CI) | p (adjusted p) | |
| ACTA1 | 1.07 (0.24–3.88) | 0.92 (>0.99) | 0.04 (0.00–1.00) | 0.13 (>0.99) | 1.56 (0.23–7.67) | 0.60 (>0.99) | 0.54 (−1.96–3.05) | 0.67 (>0.99) |
| ACTB;ACTG1 | 0.98 (0.18–4.48) | 0.98 (>0.99) | 0.10 (0.00–1.24) | 0.13 (>0.99) | 1.26 (0.13–8.62) | 0.82 (>0.99) | 1.40 (−0.67–3.46) | 0.18 (>0.99) |
| AGT | 1.18 (0.35–3.10) | 0.75 (>0.99) | 0.05 (0.00–0.67) | 0.039 (>0.99) | 0.85 (0.08–3.31) | 0.86 (>0.99) | 2.23 (0.35–4.10) | 0.02 (0.61) |
| ALDOA | 1.44 (0.30–5.26) | 0.61 (>0.99) | 0.21 (0.02–1.50) | 0.18 (>0.99) | 0.64 (0.04–4.16) | 0.70 (>0.99) | 1.47 (−0.60–3.53) | 0.16 (>0.99) |
| C1S | 0.59 (0.24–1.52) | 0.27 (>0.99) | 1.84 (0.35–11.78) | 0.49 (>0.99) | 0.78 (0.24–2.95) | 0.70 (>0.99) | 0.31 (−0.93–1.56) | 0.62 (>0.99) |
| CAT | 1.08 (0.37–2.38) | 0.86 (>0.99) | 0.03 (0.00–0.70) | 0.07 (>0.99) | 0.46 (0.03–2.21) | 0.49 (>0.99) | 0.58 (−0.85–2.00) | 0.43 (>0.99) |
| CD14 | 1.51 (0.24–9.15) | 0.65 (>0.99) | 1.19 (0.12–9.17) | 0.87 (>0.99) | 2.49 (0.20–26.48) | 0.46 (>0.99) | −0.90 (−3.43–1.63) | 0.48 (>0.99) |
| CRP | 0.35 (0.00–10.49) | 0.70 (>0.99) | 0.00 (0.00–6.39) | 0.29 (>0.99) | 2.03 (0.00–40.35) | 0.70 (>0.99) | 1.27 (−4.84–7.39) | 0.68 (>0.99) |
| CST3 | 1.56 (0.85–2.73) | 0.12 (>0.99) | 0.13 (0.01–0.73) | 0.049 (>0.99) | 2.08 (0.90–4.49) | 0.06 (>0.99) | 1.02 (−0.09–2.14) | 0.07 (>0.99) |
| GAPDH | 0.47 (0.15–1.24) | 0.17 (>0.99) | 0.47 (0.10–1.57) | 0.29 (>0.99) | 0.91 (0.22–1.81) | 0.87 (>0.99) | −0.45 (−1.31–0.41) | 0.30 (>0.99) |
| GSTO1 | 0.80 (0.14–3.34) | 0.79 (>0.99) | 0.07 (0.00–1.63) | 0.20 (>0.99) | 0.63 (0.03–4.52) | 0.72 (>0.99) | 0.81 (−1.15–2.78) | 0.41 (>0.99) |
| IGFBP2 | 1.12 (0.20–3.90) | 0.88 (>0.99) | 0.24 (0.00–2.73) | 0.46 (>0.99) | 10.63 (2.93–64.00) | 0.002 (0.046) | 2.17 (0.25–4.09) | 0.027 (0.82) |
| LBP | 2.57 (0.03–67.82) | 0.62 (>0.99) | 0.50 (0.00–102.71) | 0.82 (>0.99) | 1.09 (0.00–68.90) | 0.97 (>0.99) | 1.86 (−3.63–7.35) | 0.50 (>0.99) |
| LCP1 | 2.08 (0.81–4.80) | 0.09 (>0.99) | 1.25 (0.20–5.11) | 0.78 (>0.99) | 0.64 (0.10–2.44) | 0.59 (>0.99) | 1.48 (0.10–2.86) | 0.035 (>0.99) |
| LDHB | 1.60 (0.22–10.29) | 0.63 (>0.99) | 0.65 (0.02–13.32) | 0.80 (>0.99) | 0.61 (0.02–10.71) | 0.77 (>0.99) | 5.58 (2.58–8.57) | 0.0003 (0.009) |
| LRG1 | 1.09 (0.07–6.77) | 0.94 (>0.99) | 0.08 (0.00–2.53) | 0.34 (>0.99) | 4.89 (0.59–28.23) | 0.09 (>0.99) | 1.29 (−1.77–4.34) | 0.41 (>0.99) |
| MAN1A1 | 0.28 (0.02–2.41) | 0.32 (>0.99) | 2.55 (0.09–36.24) | 0.55 (>0.99) | 0.55 (0.02–5.54) | 0.70 (>0.99) | −0.93 (−3.37–1.50) | 0.45 (>0.99) |
| PCSK9 | 1.25 (0.33–2.78) | 0.66 (>0.99) | 1.66 (0.54–3.52) | 0.24 (>0.99) | 0.93 (0.15–2.40) | 0.92 (>0.99) | −0.02 (−1.19–1.16) | 0.98 (>0.99) |
| PDE4DIP | 0.33 (0.02–1.08) | 0.26 (>0.99) | 1.29 (0.38–3.15) | 0.61 (>0.99) | 0.88 (0.19–1.92) | 0.81 (>0.99) | 0.08 (−1.02–1.19) | 0.88 (>0.99) |
| PFN1 | 0.49 (0.08–2.16) | 0.39 (>0.99) | 0.11 (0.00–1.00) | 0.15 (>0.99) | 1.29 (0.18–7.77) | 0.79 (>0.99) | 0.50 (−1.53–2.53) | 0.63 (>0.99) |
| S100A8 | 0.16 (0.01–1.27) | 0.17 (>0.99) | 0.67 (0.04–2.26) | 0.61 (>0.99) | 1.25 (0.25–2.87) | 0.67 (>0.99) | −0.02 (−1.59–1.56) | 0.98 (>0.99) |
| SAA1 | 0.07 (0.00–4.93) | 0.68 (>0.99) | 0.39 (0.00–37.64) | 0.81 (>0.99) | 1.05 (NAa - 10.50) | 0.98 (>0.99) | −0.17 (−4.25–3.91) | 0.93 (>0.99) |
| SAA4 | 0.62 (0.16–1.98) | 0.44 (>0.99) | 0.45 (0.05–2.38) | 0.40 (>0.99) | 0.75 (0.11–3.81) | 0.75 (>0.99) | 0.22 (−1.50–1.94) | 0.80 (>0.99) |
| SERPINA1 | 0.53 (0.06–3.67) | 0.54 (>0.99) | 0.01 (0.00–0.78) | 0.08 (>0.99) | 5.13 (0.51–43.46) | 0.14 (>0.99) | 3.75 (1.27–6.24) | 0.003 (0.1) |
| SERPINA10 | 0.67 (0.10–3.79) | 0.66 (>0.99) | 1.95 (0.09–43.22) | 0.66 (>0.99) | 1.89 (0.13–22.55) | 0.62 (>0.99) | −0.26 (−2.98–2.47) | 0.85 (>0.99) |
| SERPINA3 | 1.29 (0.06–11.40) | 0.85 (>0.99) | 0.37 (0.00–5.93) | 0.56 (>0.99) | 7.76 (0.80–61.44) | 0.044 (>0.99) | 1.25 (−2.17–4.68) | 0.47 (>0.99) |
| SERPINA5 | 0.29 (0.09–0.92) | 0.038 (>0.99) | 1.52 (0.30–9.51) | 0.63 (>0.99) | 0.24 (0.04–1.17) | 0.08 (>0.99) | 0.22 (−1.39–1.83) | 0.79 (>0.99) |
| SPP2 | 0.71 (0.31–1.49) | 0.38 (>0.99) | 1.18 (0.30–4.40) | 0.81 (>0.99) | 1.12 (0.34–3.43) | 0.85 (>0.99) | −0.84 (−2.08–0.40) | 0.18 (>0.99) |
| VCAM1 | 1.80 (0.80–4.01) | 0.15 (>0.99) | 0.50 (0.05–2.94) | 0.50 (>0.99) | 1.92 (0.54–5.73) | 0.26 (>0.99) | 2.32 (0.88–3.77) | 0.002 (0.05) |
| VCL | 1.60 (0.26–9.58) | 0.60 (>0.99) | 0.09 (0.00–3.23) | 0.26 (>0.99) | 1.58 (0.18–12.07) | 0.66 (>0.99) | 1.98 (−0.59–4.54) | 0.13 (>0.99) |
a
Lower bound of profile likelihood confidence interval could not be computed.