Table 4.
Adjusted associations of perioperative change in proteins levels with postoperative outcome. Odds ratios (ORs) and 95%-confidence intervals derived from a multivariable linear regression are shown for binary outcomes, whereas regression coefficient and their 95%-confidence intervals computed with a multivariable linear regression are shown for the continuous outcome length of hospital stay. The associations are adjusted for age, gender and BMI. P-values are adjusted for multiple comparison for each outcome separately by means of the Bonferroni correction. .
| Protein | Stroke | Myocardial infarction | 1-year mortality | Length of stay | ||||
|---|---|---|---|---|---|---|---|---|
| Incidence 12/192 (6.3%) | Incidence 6/192 (3.1%) | Incidence 5/192 (2.6%) | Median 7 [IQR: 6–9 ] days | |||||
| OR (95%-CI) | p (adjusted p) | OR (95%-CI) | p (adjusted p) | OR (95%-CI) | p (adjusted p) | Beta (95%-CI) | p (adjusted p) | |
| ACTA1 | 1.72 (0.82–3.70) | 0.15 (>0.99) | 0.98 (0.24–3.29) | 0.97 (>0.99) | 2.04 (0.81–5.11) | 0.12 (>0.99) | 0.25 (−1.14–1.64) | 0.72 (>0.99) |
| ACTB;ACTG1 | 1.64 (0.82–3.39) | 0.16 (>0.99) | 0.96 (0.23–3.28) | 0.95 (>0.99) | 3.31 (1.32–8.93) | 0.011 (0.32) | 0.76 (−0.37–1.90) | 0.19 (>0.99) |
| AGT | 0.47 (0.14–1.48) | 0.21 (>0.99) | 0.79 (0.13–5.10) | 0.80 (>0.99) | 1.82 (0.29–12.16) | 0.52 (>0.99) | −1.63 (−3.44–0.18) | 0.08 (>0.99) |
| ALDOA | 1.24 (0.48–2.55) | 0.60 (>0.99) | 1.07 (0.43–2.15) | 0.86 (>0.99) | 2.00 (0.84–5.76) | 0.12 (>0.99) | 0.98 (−0.31–2.27) | 0.14 (>0.99) |
| C1S | 0.89 (0.40–1.98) | 0.78 (>0.99) | 0.94 (0.34–2.59) | 0.91 (>0.99) | 0.85 (0.30–2.40) | 0.77 (>0.99) | 0.14 (−0.87–1.16) | 0.78 (>0.99) |
| CAT | 1.33 (0.79–2.32) | 0.28 (>0.99) | 2.01 (0.63–7.04) | 0.24 (>0.99) | 1.76 (0.71–4.70) | 0.22 (>0.99) | −0.40 (−1.32–0.52) | 0.39 (>0.99) |
| CD14 | 1.61 (0.53–4.56) | 0.38 (>0.99) | 0.90 (0.17–3.79) | 0.89 (>0.99) | 1.03 (0.19–4.28) | 0.97 (>0.99) | 1.02 (−0.50–2.53) | 0.19 (>0.99) |
| CRP | 0.99 (0.22–4.70) | 0.99 (>0.99) | 0.42 (0.02–4.91) | 0.50 (>0.99) | 1.00 (0.13–7.79) | >0.99 (>0.99) | 0.21 (−1.95–2.37) | 0.85 (>0.99) |
| CST3 | 0.82 (0.38–1.52) | 0.58 (>0.99) | 0.76 (0.24–2.09) | 0.61 (>0.99) | 1.48 (0.73–2.55) | 0.17 (>0.99) | 0.82 (−0.04–1.67) | 0.06 (>0.99) |
| GAPDH | 1.62 (0.84–3.14) | 0.15 (>0.99) | 0.79 (0.40–1.88) | 0.54 (>0.99) | 1.39 (0.65–3.40) | 0.48 (>0.99) | 0.52 (−0.19–1.23) | 0.15 (>0.99) |
| GSTO1 | 2.24 (1.01–5.18) | 0.05 (>0.99) | 2.46 (0.53–12.31) | 0.24 (>0.99) | 3.85 (1.27–14.09) | 0.021 (0.62) | 0.50 (−0.80–1.81) | 0.45 (>0.99) |
| IGFBP2 | 1.23 (0.66–1.94) | 0.42 (>0.99) | 0.90 (0.20–1.93) | 0.84 (>0.99) | 1.83 (1.16–3.06) | 0.009 (0.26) | 0.96 (0.18–1.74) | 0.016 (0.48) |
| LBP | 0.51 (0.06–3.44) | 0.51 (>0.99) | 0.38 (0.04–2.66) | 0.34 (>0.99) | 0.29 (0.01–3.79) | 0.38 (>0.99) | 0.09 (−2.27–2.44) | 0.94 (>0.99) |
| LCP1 | 0.84 (0.38–1.85) | 0.67 (>0.99) | 0.82 (0.18–3.62) | 0.80 (>0.99) | 2.08 (0.68–5.95) | 0.18 (>0.99) | −0.66 (−1.77–0.46) | 0.25 (>0.99) |
| LDHB | 1.33 (0.55–2.75) | 0.48 (>0.99) | 2.23 (0.93–6.13) | 0.09 (>0.99) | 2.51 (1.07–5.80) | 0.024 (0.71) | 0.63 (−0.53–1.78) | 0.29 (>0.99) |
| LRG1 | 0.70 (0.12–3.41) | 0.67 (>0.99) | 0.21 (0.01–2.12) | 0.22 (>0.99) | 0.21 (0.02–2.02) | 0.21 (>0.99) | 1.29 (−0.68–3.27) | 0.20 (>0.99) |
| MAN1A1 | 1.16 (0.36–3.42) | 0.79 (>0.99) | 0.74 (0.12–3.88) | 0.73 (>0.99) | 0.49 (0.09–2.45) | 0.40 (>0.99) | 0.72 (−0.83–2.27) | 0.36 (>0.99) |
| PCSK9 | 0.75 (0.29–1.99) | 0.56 (>0.99) | 0.98 (0.41–2.62) | 0.97 (>0.99) | 0.77 (0.28–2.37) | 0.62 (>0.99) | −0.51 (−1.52–0.50) | 0.32 (>0.99) |
| PDE4DIP | 1.53 (1.03–2.43) | 0.048 (>0.99) | 0.44 (0.16–1.03) | 0.07 (>0.99) | 0.88 (0.49–1.55) | 0.67 (>0.99) | 0.66 (−0.08–1.40) | 0.08 (>0.99) |
| PFN1 | 1.25 (0.46–3.56) | 0.67 (>0.99) | 1.41 (0.31–7.47) | 0.67 (>0.99) | 1.84 (0.43–9.32) | 0.43 (>0.99) | 0.48 (−1.12–2.07) | 0.56 (>0.99) |
| S100A8 | 1.24 (0.87–2.16) | 0.30 (>0.99) | 0.90 (0.16–1.75) | 0.87 (>0.99) | 1.88 (1.16–3.65) | 0.022 (0.67) | −0.56 (−1.37–0.26) | 0.18 (>0.99) |
| SAA1 | 0.63 (0.14–2.48) | 0.53 (>0.99) | 0.91 (0.12–6.34) | 0.92 (>0.99) | 0.19 (0.02–1.61) | 0.16 (>0.99) | −0.57 (−2.45–1.31) | 0.55 (>0.99) |
| SAA4 | 0.76 (0.35–1.74) | 0.49 (>0.99) | 0.75 (0.25–2.27) | 0.60 (>0.99) | 0.45 (0.16–1.34) | 0.13 (>0.99) | −0.15 (−1.32–1.02) | 0.8 (>0.99) |
| SERPINA1 | 0.23 (0.03–1.30) | 0.11 (>0.99) | 1.48 (0.17–13.56) | 0.72 (>0.99) | 0.36 (0.03–3.38) | 0.39 (>0.99) | −0.74 (−3.04–1.56) | 0.53 (>0.99) |
| SERPINA10 | 0.25 (0.04–1.35) | 0.12 (>0.99) | 0.16 (0.01–2.11) | 0.19 (>0.99) | 0.57 (0.06–5.44) | 0.62 (>0.99) | −0.26 (−2.50–1.98) | 0.82 (>0.99) |
| SERPINA3 | 0.36 (0.05–2.41) | 0.30 (>0.99) | 0.74 (0.16–3.62) | 0.69 (>0.99) | 0.47 (0.04–4.57) | 0.54 (>0.99) | −0.04 (−2.24–2.15) | 0.97 (>0.99) |
| SERPINA5 | 1.97 (0.44–9.04) | 0.37 (>0.99) | 0.81 (0.09–5.95) | 0.84 (>0.99) | 10.67 (1.31–115.38) | 0.034 (>0.99) | −0.19 (−2.12–1.74) | 0.85 (>0.99) |
| SPP2 | 1.02 (0.44–2.50) | 0.97 (>0.99) | 1.10 (0.28–5.56) | 0.90 (>0.99) | 0.89 (0.27–3.42) | 0.86 (>0.99) | −0.05 (−1.42–1.31) | 0.94 (>0.99) |
| VCAM1 | 0.73 (0.33–1.57) | 0.43 (>0.99) | 2.74 (0.66–13.11) | 0.17 (>0.99) | 0.52 (0.17–1.49) | 0.24 (>0.99) | −0.33 (−1.41–0.75) | 0.55 (>0.99) |
| VCL | 2.54 (1.13–6.10) | 0.025 (0.76) | 0.70 (0.11–3.68) | 0.70 (>0.99) | 2.06 (0.86–4.70) | 0.08 (>0.99) | 0.65 (−0.63–1.94) | 0.32 (>0.99) |