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. 2024 Feb 14;35:346–361. doi: 10.1016/j.bioactmat.2024.02.011

Fig. 6.

Fig. 6

Piezoelectric stimulation modulates M2 polarization of macrophages. (A) Schematic diagram of experimental design. (B) Representative SEM images of L-RAW 264.7 cells morphology cultured with different groups. (a2-g2): high magnification pseudo-colored micrographs of the white box area in (a1-g1). Tiffany blue represents L-RAW 264.7 cells, and peachy red represents nanoparticles. (C) Representative fluorescence image of L-RAW 264.7 cells after various treatments. (D, E) Phenotype-related gene Arg-1 (D) and iNOS (E) expression of L-RAW264.7 cells after various treatments. ***p＜0.001 vs. NC US−. ###p＜0.001 significant differences between groups. (F–H) Top 20 bubble charts of the biological process (F), cellular component (G), and molecular function (H) of GO enrichment analysis in the NC US− group and t-BTO US+ group. Low q-values are in red and high q-values are in blue; the size of the circle is proportional to the number of enriched genes.