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. 2023 Dec 30;130(4):568–584. doi: 10.1038/s41416-023-02553-y

Fig. 7. The combination treatment with sertraline and RT improves in vivo immune landscape.

Fig. 7

a Box plot showing the % of tumor CD11b measured by flow cytometry in the different treatment groups of dissociated mice tumors. b From left to right; box plot showing the % of cell bound IFN-γ measured by flow cytometry in dissociated tumors collected from mice treated with DMSO, RT, sertraline, and combination treatment. Pearson correlations of cell bound IFN-γ with tumor weight. c IFN-γ, galectin-1 and granzyme B protein expression measured by immunoblot in the tumors of n ≥ 3 mice for each treatment group and n = 2 technical replicates. A Jonckheere-Terpstra test was performed. d Cytokine analysis of tumor fluids from n ≥ 3 mice for each treatment group and n = 2 technical replicates. Welch’s ANOVA test with Dunnett’s T3 multiple comparisons test was used. e Schematic representation of how ser/gly metabolites influence NK cells. Decrease levels of galectin-1 enhances the tumor-killing effects of NK cells by releasing granzyme B. Statistical analysis *p-value < 0.05, **p-value < 0.01.