FIG. 7.

Treatment of infected mice with nerolidol. Mice were infected with L. amazonensis at the left hind footpad (A) or at the basis of the tail (B and C) and treated with nerolidol for the periods indicated by horizontal arrows. (A) Mice treated intraperitoneally with 100 mg of nerolidol/kg/day (NER, ▴) or 10% ethanol in phosphate-buffered saline (C, □) for 12 days. The results shown are the mean and standard deviations for groups of five animals. Standard deviations are shown as half bars for clarity (above the symbols for control treated mice and below the symbols for nerolidol-treated mice). (B) Mice treated with ointment containing 5% (wt/wt) nerolidol in a 70% vaseline, 30% lanolin basis (LV) for 4 weeks. Control infected mice treated with the ointment basis without drug are indicated as open circles (LV). The mean for groups of five animals is shown. (C) Mice treated with ointment containing 10% (wt/wt) nerolidol in 70% vaseline, and 30% lanolin basis for 4 weeks. The mean for groups of five animals is shown. Symbols are as defined for panel A.