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. 2024 Feb 19;10:38. doi: 10.1038/s41531-024-00653-x

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — RNA was extracted from DA neurons derived from three control individuals and two sPD patients. a A volcano plot of DEGs in sPD compared to controls (|log2 fold change| > 0.5, FDR < 0.05). b Signaling network analysis with the top enriched GO cellular components pathways in sPD DA neurons compared to healthy controls (FDR < 0.05), the size of each node is proportional to the number of DEGs. c The top dysregulated (upregulated) GO cellular components pathways in sPD DA neurons compared to healthy controls (FDR < 0.01).