Table 3.
The effect of n-3 PUFA supplementation combined with 12-week structured running training on plasma Trp metabolite concentrations in trained participants.
| O-3 + TRAIN (n = 14) | TRAIN (n = 12) | rANOVA p ( | |||||
|---|---|---|---|---|---|---|---|
| PRE | POST | Δ (CI) | PRE | POST | Δ (CI) | Group x time (eta squared) | |
| 3-HK (ng/mL) | 4.73 ± 1.33 | 5.09 ± 1.73* | 0.36 (0.06;0.67) | 4.54 ± 0.71 | 4.32 ± 0.5 | − 0.22 (− 0.56;0.15) | 0.01 (0.22) |
| KYN (ng/mL) | 398.69 ± 53.57 | 403.42 ± 42.4 | 4.73 (− 27.75;37.21) | 395.74 ± 56.65 | 382.48 ± 40.86 | − 17.26 (− 52.1;17.59) | 0.32 (0.04) |
| KYNA (ng/mL) | 7.56 ± 1.82 | 8.27 ± 1.78 | 0.71 (− 0.01;1.43) | 8.75 ± 2.53 | 7.8 ± 1.95 | − 0.73 (− 2.27;0.81) | 0.06 (0.14) |
| QA (ng/mL) | 53.65 ± 14.35 | 47.44 ± 9.22 | − 6.2 (− 14.64;2.23) | 44.13 ± 8.89 | 42.98 ± 10.72 | − 2.09 (− 7.55;3.36) | 0.40 (0.03) |
| XA (ng/mL) | 3.72 ± 1.85 | 4.38 ± 3.02 | 0.66 (− 0.23;1.55) | 4.08 ± 1.22 | 3.48 ± 1.48 | − 0.52 (− 1.59;0.55) | 0.07 (0.13) |
| PA (ng/mL) | 4.5 ± 1.72 | 5.8 ± 1.81* | 1.3 (0.83;1.76) | 5.12 ± 1.47 | 5.31 ± 1.58 | 0.23 (− 0.45;0.91) | 0.01 (0.26) |
| 3-HAA (ng/mL) | 4.62 ± 1.7 | 5.04 ± 1.7 | 0.42 (− 0.08;0.92) | 4.69 ± 2.01 | 4.1 ± 1.85 | − 0.61 (-1.53;0.3) | 0.06 (0.15) |
| Trp (nmol/mL) | 55.35 ± 7.98 | 55.34 ± 8.38 | − 0.01 (− 4.17; 4.15) | 57.76 ± 8.44 | 57.95 ± 10.31 | 0.19 (− 9,84;10.22) | 0.96 (0.00) |
Values are presented as mean ± SD; 3-HK—3-hydroxykynurenine; KYN—kynurenine; KYNA—kynurenine acid; QA—Quinolinic acid; ; XA—xanthurenic acid; PA—picolinic acid; 3-HAA—3-Hydroxyanthranilic acid; Trp—tryptophan; Δ—POST to PRE changes; CI—confidence interval of changes; rANOVA—repeated measurement analysis of variance; *—statistically significant difference compared to PRE; p < 0.05.