Table 2.
Comparison of severity of prevalent ADRs between people with and without diabetes
| Prevalent ADRs | Total no. of prevalent ADRs (n = 773) n (%) |
Prevalent ADRs in people with diabetes (n = 284) n (%) |
Prevalent ADRs in people without diabetes (n = 489) n (%) |
p-value | ||
|---|---|---|---|---|---|---|
| Mild | Moderate/severe | Mild | Moderate/severe | |||
| Acute bleeding | 80 (10.3) | 4 (1.4) | 16 (5.6) | 27 (5.5) | 33 (6.7) | 0.05 |
| Acute diarrhoea | 30 (3.9) | 6 (2.1) | 8 (2.8) | 9 (1.8) | 7 (1.4) | 0.18 |
| New onset constipation | 42 (5.4) | 2 (0.7) | 9 (3.2) | 5 (1) | 26 (5.3) | 0.22 |
| Acute dyspepsia/nausea/vomiting | 59 (7.6) | 4 (1.4) | 13 (4.6) | 13 (2.7) | 29 (5.9) | 0.30 |
| Acute kidney injury (AKI) | 82 (10.6) | 20 (7) | 13 (4.6) | 26 (5.3) | 23 (4.7) | 0.32 |
| Symptomatic hypoglycaemia (SH) | 14 (1.8) | 1 (0.4) | 12 (4.2) | 0 | 1 (0.2) | < 0.001 |
| New onset fall/S | 110 (14.2) | 13 (4.6) | 23 (8.1) | 17 (3.5) | 57 (11.7) | 0.58 |
| Delirium | 39 (5.0) | 4 (1.4) | 10 (3.5) | 10 (2) | 15 (3.1) | 0.92 |
| Major serum electrolyte disturbance | 176 (22.8) | 32 (11.3) | 37 (13) | 34 (7) | 73 (14.9) | 0.23 |
| Symptomatic bradycardia | 25 (3.2) | 1 (0.4) | 5 (1.8) | 7 (1.4) | 12 (2.5) | 0.24 |
| Symptomatic orthostatic hypotension | 17 (2.2) | 3 (1.1) | 4 (1.4) | 4 (0.8) | 6 (1.2) | 0.60 |
| New onset unsteady gait | 19 (2.5) | 4 (1.4) | 5 (1.8) | 5 (1) | 5 (1) | 0.26 |
| Unspecified adverse event | 80 (10.3) | 15 (5.3) | 20 (7) | 19 (3.9) | 26 (5.3) | 0.10 |
ADRs adverse drug reactions