Table 3.
Comparison of severity of incident ADRs between people with and without diabetes
| Incident ADRs | Total no. of incident ADRs (n = 828) n (%) |
Incident ADRs in people with diabetes (n = 334) n (%) |
Incident ADRs in people without diabetes (n = 494) n (%) |
p-value | ||
|---|---|---|---|---|---|---|
| Mild | Moderate/severe | Mild | Moderate/severe | |||
| Acute bleeding | 68 (8.2) | 17 (5.1) | 9 (2.7) | 23 (4.7) | 19 (3.8) | 0.58 |
| Acute diarrhoea | 65 (7.9) | 22 (6.6) | 5 (1.5) | 28 (5.7) | 10 (2) | 0.27 |
| New onset constipation | 138 (16.7) | 7 (2.1) | 34 (10.2) | 18 (3.6) | 79 (16) | 0.16 |
| Acute dyspepsia/nausea/vomiting | 68 (8.2) | 6 (1.8) | 21 (6.3) | 17 (3.4) | 24 (4.9) | 0.42 |
| Acute kidney injury (AKI) | 99 (11.9) | 20 (6) | 27 (8.1) | 24 (4.9) | 28 (5.7) | 0.008 |
| Symptomatic hypoglycaemia (SH) | 14 (1.7) | 2 (0.6) | 12 (3.6) | 0 | 0 | < 0.001 |
| New onset fall/S | 22 (2.7) | 6 (1.8) | 4 (1.2) | 9 (1.8) | 3 (0.6) | 0.31 |
| Delirium | 44 (5.3) | 11 (3.3) | 8 (2.4) | 17 (3.4) | 8 (1.6) | 0.26 |
| Major serum electrolyte disturbance | 163 (19.7) | 24 (7.2) | 31 (9.3) | 43 (8.7) | 65 (13.2) | 0.69 |
| Symptomatic bradycardia | 11 (1.3) | 1 (0.3) | 1 (0.3) | 4 (0.8) | 5 (1) | 0.24 |
| Symptomatic orthostatic hypotension | 16 (1.9) | 2 (0.6) | 4 (1.2) | 8 (1.6) | 2 (0.4) | 0.84 |
| New onset unsteady gait | 3 (0.4) | 1 (0.3) | 0 | 1 (0.2) | 1 (0.2) | 1.00 |
| Unspecified adverse event | 117 (14.1) | 28 (8.4) | 31 (9.3) | 24 (4.9) | 34 (6.9) | 0.006 |
ADRs adverse drug reactions