TABLE 1.
MICs (μg/ml) of 299 pneumococcal strains by agar dilution
| Drug | Selected strain | MIC
|
Drug | |||
|---|---|---|---|---|---|---|
| Range | 50% | 90% | ||||
| Penicillin G | Penicillin S | 0.016-0.06 | 0.016 | 0.03 | ||
| Penicillin I | 0.12-1 | 0.25 | 1 | |||
| Penicillin R | 2-16 | 2 | 4 | |||
| Macrolide S | 0.016-4 | 2 | 2 | |||
| Macrolide R | 0.016-16 | 2 | 4 | |||
| Quinolone S | 0.016-16 | 2 | 4 | |||
| Quinolone R | 0.016-16 | 2 | 4 | |||
| Ceftobiprole | Penicillin S | 0.008-0.03 | 0.016 | 0.016 | ||
| Penicillin I | 0.008-1 | 0.06 | 0.5 | |||
| Penicillin R | 0.016-4 | 0.5 | 1 | |||
| Macrolide S | 0.008-1 | 0.25 | 0.5 | |||
| Macrolide R | 0.008-4 | 0.5 | 1 | |||
| Quinolone S | 0.008-4 | 0.5 | 0.5 | |||
| Quinolone R | 0.008-2 | 0.5 | 1 | |||
| Amoxicillin | Penicillin S | ≤0.016-0.12 | ≤0.016 | 0.03 | ||
| Penicillin I | 0.016-4 | 0.25 | 2 | |||
| Penicillin R | 0.03-16 | 2 | 8 | |||
| Macrolide S | ≤0.016-8 | 1 | 2 | |||
| Macrolide R | ≤0.016-16 | 2 | 8 | |||
| Quinolone S | ≤0.016-16 | 2 | 4 | |||
| Quinolone R | ≤0.016-8 | 2 | 4 | |||
| Imipenem | Penicillin S | ≤0.004-0.03 | 0.008 | 0.016 | ||
| Penicillin I | 0.008-0.5 | 0.03 | 0.12 | |||
| Penicillin R | 0.03-2 | 0.25 | 0.5 | |||
| Macrolide S | ≤0.004-0.5 | 0.12 | 0.25 | |||
| Macrolide R | ≤0.004-2 | 0.25 | 0.5 | |||
| Quinolone S | ≤0.004-2 | 0.25 | 0.5 | |||
| Quinolone R | ≤0.004-0.5 | 0.25 | 0.25 | |||
| Ertapenem | Penicillin S | ≤0.004-0.12 | 0.016 | 0.03 | ||
| Penicillin I | 0.016-1 | 0.12 | 0.5 | |||
| Penicillin R | 0.06-4 | 0.5 | 1 | |||
| Macrolide S | ≤0.004-1 | 0.5 | 0.5 | |||
| Macrolide R | ≤0.004-4 | 0.5 | 1 | |||
| Quinolone S | ≤0.004-4 | 0.5 | 1 | |||
| Quinolone R | ≤0.004-2 | 0.5 | 1 | |||
| Cefepime | Penicillin S | 0.03-0.12 | 0.03 | 0.06 | ||
| Penicillin I | 0.03-2 | 0.5 | 1 | |||
| Penicillin R | 0.12-32 | 1 | 2 | |||
| Macrolide S | 0.03-8 | 1 | 2 | |||
| Macrolide R | 0.03-32 | 1 | 2 | |||
| Quinolone S | 0.03-32 | 1 | 2 | |||
| Quinolone R | 0.03-4 | 1 | 2 | |||
| Ceftriaxone | Penicillin S | 0.016-0.12 | 0.016 | 0.03 | ||
| Penicillin I | 0.016-1 | 0.25 | 1 | |||
| Penicillin R | 0.12-32 | 1 | 2 | |||
| Macrolide S | 0.016-4 | 1 | 2 | |||
| Macrolide R | 0.016-32 | 1 | 4 | |||
| Quinolone S | 0.016-32 | 1 | 2 | |||
| Quinolone R | 0.016-8 | 1 | 4 | |||
| Cefotaxime | Penicillin S | 0.016-0.12 | 0.016 | 0.03 | ||
| Penicillin I | 0.016-1 | 0.25 | 1 | |||
| Penicillin R | 0.12-32 | 1 | 2 | |||
| Macrolide S | 0.016-4 | 1 | 2 | |||
| Macrolide R | 0.016-32 | 1 | 2 | |||
| Quinolone S | 0.016-32 | 1 | 2 | |||
| Quinolone R | 0.016-8 | 1 | 2 | |||
| Cefuroxime | Penicillin S | 0.016-0.25 | 0.03 | 0.12 | ||
| Penicillin I | 0.03-4 | 0.5 | 4 | |||
| Penicillin R | 1 to >64 | 4 | 16 | |||
| Macrolide S | 0.016-16 | 4 | 8 | |||
| Macrolide R | 0.03 to >64 | 4 | 16 | |||
| Quinolone S | 0.016 to >64 | 4 | 8 | |||
| Quinolone R | 0.016-32 | 4 | 16 | |||
| Cefdinir | Penicillin S | 0.06-0.25 | 0.06 | 0.12 | ||
| Penicillin I | 0.06-8 | 0.5 | 8 | |||
| Penicillin R | 0.25 to >64 | 8 | 16 | |||
| Macrolide S | 0.06-32 | 8 | 16 | |||
| Macrolide R | 0.06 to >64 | 8 | 16 | |||
| Quinolone S | 0.06 to >64 | 8 | 16 | |||
| Quinolone R | 0.06-16 | 8 | 16 | |||
| Levofloxacin | Penicillin S | 0.5-32 | 2 | 16 | ||
| Penicillin I | 0.5-16 | 1 | 2 | |||
| Penicillin R | 0.5-32 | 1 | 4 | |||
| Macrolide S | 0.5-32 | 1 | 16 | |||
| Macrolide R | 0.5-32 | 1 | 2 | |||
| Quinolone S | 0.5-2 | 1 | 2 | |||
| Quinolone R | 4-32 | 16 | 32 | |||
| Moxifloxacin | Penicillin S | 0.06-4 | 0.25 | 4 | ||
| Penicillin I | ≤0.03-4 | 0.12 | 0.25 | |||
| Penicillin R | ≤0.03-8 | 0.12 | 0.5 | |||
| Macrolide S | 0.06-8 | 0.25 | 2 | |||
| Macrolide R | ≤0.03-8 | 0.12 | 0.5 | |||
| Quinolone S | ≤0.03-1 | 0.12 | 0.25 | |||
| Quinolone R | 0.25-8 | 2 | 8 | |||
| Azithromycin | Penicillin S | 0.06 to >64 | 0.12 | >64 | ||
| Penicillin I | ≤0.016 to >64 | 0.25 | >64 | |||
| Penicillin R | ≤0.016 to >64 | 4 | >64 | |||
| Macrolide S | ≤0.016-0.5 | 0.12 | 0.25 | |||
| Macrolide R | 1 to >64 | >64 | >64 | |||
| Quinolone S | ≤0.016 to >64 | 4 | >64 | |||
| Quinolone R | ≤0.016 to >64 | 0.12 | >64 | |||
| Clarithromycin | Penicillin S | ≤0.016 to >64 | 0.06 | >64 | ||
| Penicillin I | ≤0.016 to >64 | 0.06 | >64 | |||
| Penicillin R | ≤0.016 to >64 | 1 | >64 | |||
| Macrolide S | ≤0.016-0.5 | 0.03 | 0.06 | |||
| Macrolide R | 0.25 to >64 | >64 | >64 | |||
| Quinolone S | ≤0.016 to >64 | 1 | >64 | |||
| Quinolone R | ≤0.016 to >64 | 0.06 | >64 | |||
| Linezolid | Penicillin S | 0.25-2 | 1 | 2 | ||
| Penicillin I | 0.25-4 | 1 | 2 | |||
| Penicillin R | 0.25-4 | 1 | 2 | |||
| Macrolide S | 0.25-4 | 1 | 2 | |||
| Macrolide R | 0.25-2 | 1 | 2 | |||
| Quinolone S | 0.25-4 | 1 | 2 | |||
| Quinolone R | 0.5-2 | 1 | 2 | |||
| Quinupristin-dalfopristin | Penicillin S | 0.12-1 | 0.5 | 1 | ||
| Penicillin I | ≤0.06-1 | 0.5 | 1 | |||
| Penicillin R | 0.12-1 | 0.5 | 1 | |||
| Macrolide S | ≤0.06-1 | 0.5 | 0.5 | |||
| Macrolide R | 0.12-1 | 0.5 | 1 | |||
| Quinolone S | ≤0.06-1 | 0.5 | 1 | |||
| Quinolone R | 0.12-1 | 0.5 | 1 | |||
| Daptomycin | Penicillin S | 0.06-0.25 | 0.12 | 0.12 | ||
| Penicillin I | 0.06-0.5 | 0.12 | 0.25 | |||
| Penicillin R | 0.06-0.5 | 0.12 | 0.25 | |||
| Macrolide S | 0.06-0.5 | 0.12 | 0.25 | |||
| Macrolide R | 0.06-0.25 | 0.12 | 0.25 | |||
| Quinolone S | 0.06-0.5 | 0.12 | 0.25 | |||
| Quinolone R | 0.06-0.25 | 0.12 | 0.25 | |||
| Vancomycin | Penicillin S | 0.12-0.5 | 0.25 | 0.25 | ||
| Penicillin I | ≤0.016-0.5 | 0.25 | 0.5 | |||
| Penicillin R | 0.12-0.5 | 0.25 | 0.5 | |||
| Macrolide S | 0.12-0.5 | 0.25 | 0.5 | |||
| Macrolide R | ≤0.016-0.5 | 0.25 | 0.5 | |||
| Quinolone S | ≤0.016-0.5 | 0.25 | 0.5 | |||
| Quinolone R | 0.12-0.5 | 0.25 | 0.5 | |||
| Teicoplanin | Penicillin S | ≤0.016-0.12 | 0.03 | 0.06 | ||
| Penicillin I | ≤0.016-0.12 | 0.03 | 0.06 | |||
| Penicillin R | ≤0.016-0.25 | 0.06 | 0.12 | |||
| Macrolide S | ≤0.016-0.12 | 0.06 | 0.12 | |||
| Macrolide R | ≤0.016-0.25 | 0.06 | 0.12 | |||
| Quinolone S | ≤0.016-0.25 | 0.06 | 0.12 | |||
| Quinolone R | ≤0.016-0.12 | 0.06 | 0.12 | |||
| Telithromycin | Penicillin S | 0.008-1 | 0.016 | 0.5 | ||
| Penicillin I | ≤0.004-1 | 0.03 | 0.12 | |||
| Penicillin R | ≤0.004-4 | 0.03 | 0.5 | |||
| Macrolide S | ≤0.004-0.12 | 0.016 | 0.03 | |||
| Macrolide R | 0.008-4 | 0.12 | 1 | |||
| Quinolone S | ≤0.004-4 | 0.03 | 0.5 | |||
| Quinolone R | 0.008-1 | 0.016 | 0.25 | |||