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. 2005 May;49(5):1932–1942. doi: 10.1128/AAC.49.5.1932-1942.2005

TABLE 3.

Results of time-kill studies

Drug and concn No. of strains with the indicated decreasea at:
3 h
6 h
12 h
24 h
−1 −2 −3 −1 −2 −3 −1 −2 −3 −1 −2 −3
Ceftobiprole
    4× MIC 12 4 0 12 9 3 12 12 10 12 12 12
    2× MIC 11 4 0 12 9 2 12 12 10 12 12 11
    MIC 9 1 0 12 6 1 12 11 9 11 11 10
Amoxicillin
    4× MIC 12 5 0 12 11 5 12 12 11 12 12 12
    2× MIC 11 3 0 12 11 5 12 12 9 12 12 12
    MIC 10 2 0 12 7 1 12 12 5 10 10 9
Imipenem
    4× MIC 12 7 3 12 11 4 12 12 10 12 12 12
    2× MIC 12 5 2 12 10 4 12 12 10 12 11 11
    MIC 11 3 2 12 10 4 12 12 8 12 11 10
Ertapenem
    4× MIC 12 3 0 12 10 3 12 12 11 12 12 12
    2× MIC 12 4 0 12 9 3 12 12 12 12 12 12
    MIC 9 3 0 12 8 2 12 11 9 11 10 9
Cefepime
    4× MIC 12 2 1 11 11 2 12 12 10 12 12 12
    2× MIC 11 2 1 11 11 1 12 12 10 12 12 12
    MIC 11 1 1 11 9 1 11 11 10 11 11 11
Ceftriaxone
    4× MIC 12 5 1 12 11 2 12 12 11 12 12 12
    2× MIC 11 5 1 12 11 2 12 12 11 12 12 12
    MIC 11 5 1 12 10 2 12 12 8 11 11 8
Cefotaxime
    4× MIC 12 2 0 12 7 1 12 12 9 12 12 12
    2× MIC 11 2 0 12 7 1 12 11 9 12 12 12
    MIC 9 2 0 12 6 1 11 11 9 12 11 9
Cefuroxime
    4× MIC 12 3 0 12 11 2 12 12 10 12 12 12
    2× MIC 11 2 0 12 11 1 12 12 10 12 12 12
    MIC 9 2 0 11 8 1 11 11 8 11 9 8
Cefdinir
    4× MIC 10 3 0 11 9 2 12 12 10 12 12 12
    2× MIC 9 2 0 11 9 2 12 12 8 12 12 12
    MIC 8 2 0 10 8 2 12 11 5 12 11 9
Levofloxacin
    4× MIC 11 6 1 11 9 3 12 12 10 12 12 12
    2× MIC 9 6 1 11 7 2 12 12 10 12 12 12
    MIC 6 1 0 0 5 0 12 11 7 12 9 9
Moxifloxacin
    4× MIC 11 3 0 12 9 2 12 12 10 12 12 12
    2× MIC 10 1 0 12 9 1 12 12 9 12 12 11
    MIC 7 0 0 12 2 0 12 9 4 12 10 6
Azithromycinb
    4× MIC 2 0 0 5 1 0 5 4 3 6 6 4
    2× MIC 2 0 0 5 1 0 4 4 2 6 5 3
    MIC 0 0 0 4 1 0 4 3 2 6 5 2
Clarithromycinb
    4× MIC 4 0 0 3 2 0 6 5 2 5 5 4
    2× MIC 3 0 0 3 1 0 5 3 2 5 5 4
    MIC 3 0 0 3 0 0 5 1 1 5 5 1
Linezolid
    4× MIC 2 0 0 9 0 0 11 6 1 12 11 3
    2× MIC 1 0 0 6 0 0 11 3 0 12 10 2
    MIC 0 0 0 3 0 0 6 0 0 10 4 0
Quinupristin- dalfopristin
    4× MIC 12 12 8 12 12 11 12 12 11 12 12 11
    2× MIC 12 11 8 12 12 11 12 12 11 12 12 11
    MIC 12 11 7 12 12 9 12 12 11 10 9 8
Daptomycin
    4× MIC 12 10 3 12 10 6 12 12 12 12 12 12
    2× MIC 10 8 0 12 10 5 12 12 10 12 12 12
    MIC 10 3 0 12 9 2 12 12 9 9 7 4
Vancomycin
    4× MIC 10 3 1 12 9 1 12 11 8 12 12 10
    2× MIC 10 2 1 11 9 1 12 11 7 12 12 10
    MIC 6 2 1 10 8 1 12 11 4 11 11 9
Teicoplanin
    4× MIC 4 0 0 7 1 0 11 10 3 12 12 10
    2× MIC 3 0 0 6 1 0 11 9 1 12 12 10
    MIC 2 0 0 6 1 0 11 9 1 11 11 8
Telithromycin
    4× MIC 7 3 0 9 4 1 12 8 3 12 11 8
    2× MIC 4 2 0 9 4 1 12 5 2 11 11 5
    MIC 4 1 0 6 3 1 9 2 1 10 7 2
a

−1, 90% killing; −2, 99% killing; −3, 99.9% killing.

b

Only eight strains with MICs of <8 μg/ml were tested.