Table 1.
Ksucc sites, Location of distribution, Related disease of identified succinylated proteins.
| Functional classification | Succinylated protein | Ksucc sites | Location of distribution | Related disease | References |
|---|---|---|---|---|---|
| Regulation of glucose metabolism | Histone H4 | K5, K12 | The germ cells of testes | Male reproductive injury | (16) |
| Phosphoglycerate mutase 1(PGAM1) | K99 | Cancer cells | Liver cancer | (18) | |
| lactate dehydrogenase A (LDHA) | k222 | Cancer and adjacent tissues | Gastric cancer(GC) | (19) | |
| Regulation of amino acid metabolism | S100A10 | K47 | Cancer cells | GC | (46) |
| fibrillin 1(FBN1) | k672 | Cancer cells | GC | (47) | |
| kidney-type glutaminase (GLS) | K311 | blood serum and Cancer cells | metabolic diseases and cancer | (22, 44) | |
| Regulation of fatty acid metabolism | cardiac proteins:ECHA | heart | hypertrophic cardiomyopathy, | (53) | |
| enoyl-CoA hydratase (EchA19) | K132, K139 | Mycobacterium tuberculosis (Mtb) | infection | (54) | |
| Regulation of ketone body synthesis | 3-ketoacid-CoA transferase(SCOT) | / | Skeletal muscle | hyperglycemia | (23) |
| cardiac protein O-GlcNAcase | / | diabetic myocardium | type 2 diabetes mellitus and heart failure | (61) | |
| The ketoglutarate dehydrogenase complex (KGDHC) | / | Brain(all cortical cells) | neurodegenerative diseases | (6) | |
| Redox regulation | Pyruvate kinase M2 (PKM2) | Cancer cells | colon cancer | (41) | |
| LDHA and SDHA | vascular smooth muscle cells | aortic aneurysm and dissection (AAD) | (20) | ||
| GTPase Cdc42 | serum and brain tissue | occlusion of the middle cerebral artery | (30) | ||
| Others | Nucleosomal histone H4 | K77 | tumor cells | DNA repair defect | (50) |
| Nucleosomal histone H3 | K79, K122 | Liver cells | HBV-infected | (11, 68) | |
| CTBP1 | K46, K280 | Cancer cells | prostate cancer | (63) | |
| Influenza virusviral nucleoprotein | K87 | lung | Influenza virus infection | (49) | |
| HCMEC/D3 protein (TAGLN2) | K40 | Tumor cells | gliomas | (33) |