Fig. 7.

The role of ASMase in arterial relaxation after intraperitoneal (i.p.) injection of recombinant mouse TNF-α (a, b) Cumulative concentration-dependent Ach-induced relaxation of mouse aortic vessels in the absence (a) and presence of L-NAME (b). (c) The relaxation concentration-response curve to SNP was attained in mouse aortic vessels. (d) Maximum relaxation of aortic vessels with or without L-NAME in response to 10^-6 M Ach. Data are represented as the mean±SEM (n = 5). All the experiments were performed independently three times. *P < 0.05, **P < 0.01, ***P < 0.001 vs WT; ^#P < 0.05, ^##P < 0.01, ^###P < 0.001 vs WT- TNF-α