TABLE 6.
Logistic regression analysis for factors associated with class X drug-drug interactions in the study population.
| Variable | With X (n = 48) | Without X (n = 66) | p |
|---|---|---|---|
| Age, years | 54.81 ± 17.18 | 54.33 ± 13.65 | 0.869 |
| Age, ≥ 65 | 35 (72.9%) | 54 (81.8%) | 0.257 |
| Gender, male (%) | 38 (79.2%) | 55 (83.3%) | 0.571 |
| Gender, female (%) | 10 (20.8%) | 11 (16.7%) | |
| BMI, kg/m2 | 21.09 ± 4.58 | 19.80 ± 4.48 | 0.135 |
| APACHE Ⅱ score | 12 (10,19) | 10 (6,12) | <0.001 |
| Length of ICU stay, days | 26 (15,36) | 7 (14,26) | <0.001 |
| Primary disease (%) | |||
| Pulmonary hypertension | 10 (20.8%) | 22 (33.3%) | 0.143 |
| Interstitial lung disease | 25 (52.1%) | 36 (54.5%) | 0.795 |
| Bronchiectasis | 8 (16.7%) | 3 (4.5%) | 0.065 |
| Chronic obstructive pulmonary disease | 12 (25.0%) | 20 (30.3%) | 0.534 |
| Pulmonary infection | 17 (35.4%) | 19 (28.8) | 0.452 |
| Silicosis | 6 (12.8%) | 13 (19.7%) | 0.332 |
| Comorbidities (%) | |||
| Diabetes mellitus | 8 (16.7%) | 13 (19.7%) | 0.680 |
| Hypertension | 12 (25.0%) | 9 (13.6%) | 0.122 |
| Malignancy | 4 (8.3%) | 1 (1.5%) | 0.196 |
| Cerebrovascular accident | 1 (2.1%) | 3 (4.5%) | 0.849 |
| Infectious disease | 41 (85.4%) | 44 (66.7%) | 0.023 |
| Past drug allergy (%) | |||
| Yes | 13 (27.1%) | 11 (16.7%) | 0.178 |
| No | 35 (72.9%) | 55 (83.3%) | |
| Number of drugs per patient | 40 (32,47) | 30 (25,34) | <0.001 |
| Number of DDIs per patient | 45 (30,67) | 25 (16,34) | <0.001 |