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. 2024 Feb 19;15:1493. doi: 10.1038/s41467-024-45665-6

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — Normalized Enrichment Scores (NES) in bulk tissue transcriptomic data comparing (a) pre- and post-treatment samples for VDZ responders (R) and non-responders (NR), (b) pre-VDZ R vs NR (red bars FDR < 0.1, gray bars FDR > 0.1). c Leading edge analysis of significantly enriched gene sets. d–g, GSEA of VDZ response and non-response spatial signatures in external cohort of patients (d) pre-VDZ and (f) pre-IFX. Subset of genes comprising the leading edge of the NES and FDR q-values in (e) pre-VDZ and (g) pre-IFX patients, respectively. IFX infliximab.