TABLE 1.
Differential metabolites and identification results in feces of control group and model group.
| No. | m/z | RT | VIP | Accepted Compound ID | Accepted description | Chemical formula | Trend (M/C) | Trend (CBD/M) |
|---|---|---|---|---|---|---|---|---|
| MOD vs. CON—Positive ion mode | ||||||||
| 1 | 524.3721779 | 10.9483 | 5.46494 | HMDB0010384 | LysoPC(18:0/0:0) | C26H54NO7P | ↑ | ↓ |
| 2 | 496.3403241 | 9.6576 | 5.23954 | HMDB0010382 | LysoPC(16:0/0:0) | C24H50NO7P | ↑ | ↓ |
| 3 | 260.1243408 | 0.41125 | 1.42272 | HMDB0038516 | Linatine | C10H17N3O5 | ↓ | ↑ |
| 4 | 165.0551008 | 0.64695 | 3.09474 | HMDB0012225 | Enol-phenylpyruvate | C9H8O3 | ↓ | ↑ |
| 5 | 220.1183701 | 1.352116667 | 2.89193 | HMDB0000210 | Pantothenic acid | C9H17NO5 | ↓ | ↓ |
| 6 | 279.2329643 | 10.10745 | 6.30105 | HMDB0030964 | Linolenelaidic acid | C18H30O2 | ↓ | ↑ |
| 7 | 279.232538 | 9.193433333 | 3.92259 | HMDB0001388 | alpha-Linolenic acid | C18H30O2 | ↓ | ↑ |
| 8 | 281.2482 | 9.41 | 2.37703 | HMDB0000673 | Linoleic acid | C18H32O2 | ↓ | ↑ |
| 9 | 124.0396934 | 0.547016667 | 1.86816 | HMDB0001488 | Nicotinic acid | C6H5NO2 | ↓ | ↑ |
| 10 | 211.1336099 | 2.857 | 1.47174 | HMDB0032797 | Jasmonic acid | C12H18O3 | ↓ | ↑ |
| 11 | 249.149555 | 3.176633333 | 1.38857 | HMDB0303940 | (+)-cis-abscisic aldehyde | C15H20O3 | ↓ | ↑ |
| 12 | 273.1854366 | 5.872183333 | 1.49869 | HMDB0000429 | 17alpha-Estradiol | C18H24O2 | ↓ | ↑ |
| 13 | 273.1854748 | 6.134733333 | 1.53055 | HMDB0000151 | Estradiol | C18H24O2 | ↓ | ↑ |
| 14 | 273.221961 | 6.5137 | 3.28136 | HMDB0000031 | Androsterone | C19H30O2 | ↑ | ↓ |
| 15 | 301.2168962 | 6.5065 | 3.22035 | HMDB0012329 | 4-Oxoretinol | C20H28O2 | ↑ | ↓ |
| 16 | 375.2889103 | 7.318933333 | 2.19236 | HMDB0000626 | Deoxycholic acid | C24H40O4 | ↓ | ↑ |
| 17 | 443.3534141 | 9.72185 | 1.71234 | HMDB0001181 | 4a-Carboxy-4b-methyl-5a-cholesta-8,24-dien-3b-ol | C29H46O3 | ↓ | ↑ |
| 18 | 303.2326896 | 11.41801667 | 8.11816 | HMDB0001999 | Eicosapentaenoic acid | C20H30O2 | ↑ | ↓ |
| 19 | 239.2377016 | 12.13921667 | 1.25757 | HMDB0000220 | Palmitic acid | C16H32O2 | ↑ | ↓ |
| 20 | 267.2689637 | 13.40715 | 1.00923 | HMDB0000827 | Stearic acid | C18H36O2 | ↑ | ↓ |
| 21 | 399.3259154 | 10.1986 | 2.36038 | HMDB0001903 | Calcitriol | C27H44O3 | ↑ | ↓ |
| 22 | 443.3524799 | 10.81978333 | 4.93951 | HMDB0006927 | 4a-Methylzymosterol-4-carboxylic acid | C29H46O3 | ↓ | ↓ |
| 23 | 277.2171 | 9.36 | 1.59643 | HMDB0006547 | Stearidonic acid | C18H28O2 | ↓ | ↑ |
| 24 | 279.2326771 | 11.37518333 | 3.80514 | HMDB0004670 | alpha-Dimorphecolic acid | C18H32O3 | ↓ | ↑ |
| 25 | 261.2220695 | 10.477 | 1.09251 | HMDB0003073 | gamma-Linolenic acid | C18H30O2 | ↓ | ↑ |
| 26 | 385.3464928 | 10.45558333 | 1.14543 | HMDB0002719 | Desmosterol | C27H44O | ↓ | ↑ |
| 27 | 301.216959 | 10.37706667 | 1.76909 | HMDB0031817 | Cuminyl alcohol | C10H14O | ↑ | ↓ |
| 28 | 271.2064185 | 10.00038333 | 1.23567 | HMDB0000234 | Testosterone | C19H28O2 | ↑ | ↓ |
| 29 | 301.2169715 | 9.102216667 | 4.26086 | HMDB0001852 | all-trans-Retinoic acid | C20H28O2 | ↑ | ↑ |
| 30 | 300.2905781 | 8.588216667 | 2.18291 | HMDB0000252 | Sphingosine | C18H37NO2 | ↓ | ↑ |
| 31 | 431.2771544 | 6.134733333 | 1.16411 | HMDB0000619 | Cholic acid | C24H40O5 | ↓ | ↑ |
| 32 | 297.1850747 | 6.100683333 | 1.33434 | HMDB0006285 | 4-oxo-Retinoic acid | C20H26O3 | ↑ | ↓ |
| 33 | 149.0600879 | 5.56515 | 1.59227 | HMDB0005175 | Homovanillin | C9H10O3 | ↓ | ↑ |
| 34 | 180.1022107 | 3.776316667 | 2.16326 | HMDB0060335 | 1,2-Dihydronaphthalene-1,2-diol | C10H10O2 | ↑ | ↑ |
| 35 | 176.0701606 | 3.633533333 | 1.20156 | HMDB0034250 | Betamipron | C10H11NO3 | ↑ | ↑ |
| 36 | 260.1243065 | 0.561283333 | 1.06424 | HMDB0000273 | Thymidine | C10H14N2O5 | ↓ | ↑ |
| 37 | 300.2906 | 11.16 | 3.29904 | HMDB0012095 | Sphingomyelin | C47H95N2O6P | ↑ | ↓ |
| 38 | 302.3064 | 8.87 | 1.87497 | HMDB0000269 | Sphinganine | C18H39NO2 | ↑ | ↓ |
| 39 | 566.3469 | 9.97 | 1.54872 | HMDB0002815 | LysoPC[18:1(9Z)/0:0] | C26H52NO7P | ↑ | ↓ |
| MOD vs. CON—Negative ion mode | ||||||||
| 1 | 303.233 | 1.189733333 | 1.76543 | HMDB0010395 | LysoPC(20:4/0:0) | C28H50NO7P | ↑ | ↓ |
| 2 | 283.2643 | 7.34 | 2.65433 | HMDB0060501 | Phosphatidylethanolamine | C41H82NO8P | ↑ | ↓ |
| 3 | 347.217107 | 6.41315 | 1.4273 | HMDB0000517 | L-Arginine | C6H14N4O2 | ↑ | ↓ |
| 4 | 439.2451664 | 9.0732 | 2.27467 | HMDB0011154 | LysoPA(P-16:0/0:0) | C19H39O6P | ↑ | ↓ |
| 5 | 289.0664494 | 3.46905 | 2.85598 | HMDB0001552 | 2-Keto-glutaramic acid | C5H7NO4 | ↓ | ↑ |
| 6 | 87.0512667 | 1.887416667 | 2.4044 | HMDB0000788 | Orotidine | C10H12N2O8 | ↓ | ↓ |
| 7 | 159.0925687 | 5.615116667 | 1.44012 | HMDB0000303 | Tryptamine | C10H12N2 | ↑ | ↓ |