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. 2024 Jan;25(1):88–100. doi: 10.1016/j.jpain.2023.07.023

Figure 4.

Figure 4

Oxaliplatin did not alter the firing rate or cold activation thresholds in C-fibers. Oxaliplatin treatment did not affect the firing rate evoked by mechanical force steps in CM or CMC units. CMC (A) and CM (B) fibers respond to mechanical force steps by firing similar numbers of action potentials before and after vehicle and oxaliplatin (P > .05, 2-way RM ANOVA, n = 7–10). The number of action potentials (C) and the peak firing frequency (D) evoked by cold in CMCs were unchanged by oxaliplatin or vehicle treatment (n = 10). (E) The temperature threshold for cold activation of CMCs was unchanged by vehicle or oxaliplatin treatment (n = 10). Abbreviation: ANOVA, analysis-of-variance.