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In vivo effect of anti-miRNA103/107-loaded LNPs on ischemic volume of rats subjected to tMCAO followed by 24 h from reperfusion
Ischemic damage was assessed in rats subjected to tMCAO and treated with four bolus injections of LNPs through the caudal vein 24 and 18 h before tMCAO induction, and 1 and 5 h after reperfusion. Vehicle group represents animals treated with tMCAO and saline solution. Each column represents the mean ± SEM. ∗p < 0.05 vs. vehicle group.
