Table 1.
Lipid composition of LNPs (molar ratio) | |||||||
---|---|---|---|---|---|---|---|
Formulation | DSPC | CHOL | DODAP | PEG2000-Cer16 | DSPE-PEG-Mal | Surface conjugation | Anti-miR103/107theoretical loading (nmol/mg lipids) |
LNP | 1 | 1.8 | 0.8 | 0.4 | – | – | – |
LNP 1 | 1 | 1.8 | 0.8 | 0.4 | – | – | 27.6 |
LNP 2 | 1 | 1.8 | 2 | 0.4 | – | – | 41.4 |
LNP 3 | 1 | 1.8 | 0.8 | 0.2 | 0.2 | Transferrin | 27.6 |
LNP 4 | 1 | 1.8 | 2 | 0.2 | 0.2 | Transferrin | 41.4 |