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Abnormalities of ABCA5-deficient mice. Weakened mice exhibited an enlarged abdomen (A) and exophthalmos (B, right) at the end of their lives. The Abca5−/− mice developed an enlarged heart (C, left) and injured liver (D, left). Anatomical observation was performed after perfusion and fixation with 4% paraformaldehyde. (E) Hematoxylin and eosin staining of the liver sections prepared from wild-type (left panel) and Abca5−/− (right panel) mice. Bars, 100 μm.
