Inhibition of endogenous H2S production aggravated DoIC, which was partially rescued by exogenous H2S supplementation.
A, Body weight of mice (n = 6). B, Ratio of heart weight to tibia length (HW/TL, n = 6). C, Representative M-mode images of transthoracic echocardiography. D and E, Quantification of left ventricular ejection fraction and left ventricular fraction shortening (n = 6). F and G, The expression levels of Anp and Bnp mRNA in heart tissues. H, Representative images of H&E staining in heart sections (Scale bar indicated 20 μm). I, Representative images of Masson's trichrome staining in heart sections (Scale bar indicated 20 μm). J, Representative transmission electron micrographs of heart tissues (Scale bar indicated 1 μm). The data are presented as the Mean ± SD. **p < 0.01 and ***p < 0.001 vs. Vehicle group at the same genetic background; #p < 0.05, ##p < 0.01 and ###p < 0.001 vs. DOX group of Csef/f/cre−; &&&p < 0.001 vs. DOX group of Csef/f/cre+.