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. 2023 Nov 8;33(5):387–399. doi: 10.1093/hmg/ddad191

Figure 2.

Figure 2

Intrinsic excitability of zQ175 sensory cortical pyramidal neurons decreases over time. (A) Representative traces of voltage responses to somatic current injections recorded from sensory cortical pyramidal neurons (CPNs) at 3–4 and 8–9 months for wildtype (WT) and zQ175 mice. (B–D) Resting membrane potential (B), rheobase (C) and number of action potentials as a function of depolarizing current injections above the rheobase (D) (# denotes statistical difference between 3–4 month (m) HD and 3–4 m WT; * denotes statistical difference between 8–9 m HD and 8–9 m WT) (3–4 m WT: solid triangles and zQ175: open triangles; 8–9 m WT: solid circles and zQ175: open circles) (n = 10–20 from 4–5 mice for each group). Error bars denote SE. * or #, ** or ##, *** and NS denotes P < 0.05, 0.01, 0.005 and statistically non-significant, respectively.