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. 2023 Nov 8;33(5):387–399. doi: 10.1093/hmg/ddad191

Figure 3.

Figure 3

Large-amplitude excitatory discharges induced by picrotoxin are more frequent and complex in sensory cortical pyramidal neurons from zQ175 mice. (A) Representative large-amplitude excitatory discharges recorded from sensory cortical pyramidal neurons (CPNs) at 3–4 and 8–9 months for wildtype (WT) and zQ175 mice at a holding potential of −70 mV in the presence of 50 μM picrotoxin. (A, Insets) Expanded view of large-amplitude discharges showing slow decay to baseline (dotted line). (B–D) Percent of cells with discharges (B), discharge frequency (C) and percent of cells with complex discharges (D). (E and F) Distribution of discharge duration from 3–4 (E) and 8–9 (F) month WT and zQ175 mice (n = 10–14 from 4–5 mice for each group). Error bars denote SE. *, *** and NS denotes P < 0.05, 0.005 and statistically non-significant, respectively.