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. 2023 Nov 8;33(5):387–399. doi: 10.1093/hmg/ddad191

Figure 4.

Figure 4

Increased excitability in motor cortical pyramidal neurons from 8–9 month zQ175 mice. (A) Representative traces of voltage responses to somatic current injections (left panel) and spontaneous excitatory postsynaptic currents (sEPSCs; right panel) recorded from motor cortical pyramidal neurons (CPNs) at 8–9 months for wildtype (WT) and zQ175 mice. (B and C) Cumulative probability of amplitude (B) and frequency (C) zQ175 and WT with corresponding mean amplitude and frequency shown in insets (n = 10–11 from 4–5 mice for each group). (D–E) Resting membrane potential (D left panel), rheobase (D right panel) and number of action potentials as a function of depolarizing current injections above the rheobase (E) (n = 11–13 from 4–5 mice for each group). Error bars denote SE. *, *** and NS denotes P < 0.05, 0.005 and statistically non-significant, respectively.