Skip to main content
. 2023 Nov 8;33(5):387–399. doi: 10.1093/hmg/ddad191

Figure 5.

Figure 5

Large-amplitude discharges induced by picrotoxin are more complex in motor cortical pyramidal neurons from zQ175 mice. (A) Representative large-amplitude discharges recorded from motor cortical pyramidal neurons (CPNs) at 8–9 months for wildtype (WT) and zQ175 mice at a holding potential of −70 mV in the presence of 50 μM picrotoxin. (B and D) Percent Of cells with discharges (B), discharge frequency (C) and percent of cells with complex discharges (D). (E) Distribution of the duration of discharges from 8–9 month WT (solid bars) and zQ175 mice (checkered bars) (n = 11–17 from 4–5 mice for each group). Error bars denote SE. NS denotes statistically non-significant.