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. 2023 Nov 8;33(5):387–399. doi: 10.1093/hmg/ddad191

Figure 6.

Figure 6

Reduced fast-spiking interneuron intrinsic excitability in the sensory but not motor cortex of zQ175 mice at 8–9 months. (A) Representative traces of voltage responses to somatic current injections recorded from sensory (top panels) and motor (bottom panels) fast-spiking interneurons (FSIs) at 8–9 months for wildtype (WT) and zQ175 mice. (B and C) CPN and FSI spike half-width as a function of maximal firing frequency (FF) from zQ175 (B) and WT (C) mice. (D–I) Resting membrane potential (D and G) and rheobase (E and H) from sensory (D and E) (n = 6–7 (4–5 mice) per group) and motor (G and H) (n = 5–6 (4–5 mice) per group) FSIs. Number of action potentials as a function of depolarizing current injections above the rheobase from sensory (F) and motor (I) FSIs (zQ175: open diamond or triangle; WT: solid diamond or triangle). Error bars denote SE. *, **, *** and NS denotes P < 0.05, 0.01, 0.005 and statistically non-significant, respectively.