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. 2023 Nov 8;33(5):387–399. doi: 10.1093/hmg/ddad191

Figure 7.

Figure 7

Inhibitory synaptic input is reduced and excitatory-inhibitory (E-I) ratio is larger in the sensory cortex of 8–9 month zQ175 mice. (A) Representative traces of spontaneous inhibitory postsynaptic currents (sIPSCs) recorded from sensory cortical pyramidal neurons (CPNs) at 8–9 months for wildtype (WT) and zQ175 mice at a holding potential of +10 mV. (B and C) Cumulative probability of sIPSC amplitude (B) and frequency (C) with corresponding mean amplitude and frequency shown in insets (n = 11–14 (3–4 mice) per group). (D–F) All excitatory-inhibitory ratio experiments were conducted in the presence of 50 μM D-APV. (D) Representative evoked excitatory postsynaptic current (eEPSC) recorded at a holding potential of −70 mV, and evoked inhibitory postsynaptic current (eIPSC) recorded at a holding potential of +10 mV from layer II/III sensory CPNs in response to stimulation in layer IV. (E) Representative blockade of eIPSC after treatment with 10 μM CNQX (upper panel) or 50 μM picrotoxin (PTX) (lower panel). (F) E-I ratio of layer II/III sensory CPNs (n = 9–11 (3 mice) per group). Error bars denote SE. * denotes P < 0.05.