Table 1.
Cortical pyramidal neuron membrane properties of 3–4 and 8–9 month old zQ175 and WT mice.
| Cm (pF) | Rm (MΩ) | ||
|---|---|---|---|
| Sensory cortex | |||
| 3–4 months | |||
| zQ175 (13) | 99.5 ± 9.2 | 142.3 ± 10.1 | |
| WT (20) | 119.9 ± 6.0 | 136.4 ± 7.8 | |
| 8–9 months | |||
| zQ175 (19) | 102.3 ± 4.7 | 156.1 ± 7.8 | |
| WT (19) | 111.9 ± 7.3 | 143.1 ± 8.5 | |
| CsMe zQ175 (20) | 113.8 ± 6.4 | 136.8 ± 9.5 | |
| CsMe WT (21) | 107.1 ± 5.7 | 147.2 ± 8.9 | |
| Motor cortex | |||
| 8–9 months | |||
| zQ175 (16) | 119.5 ± 7.4 | 132.7 ± 9.5 | |
| WT (14) | 108.3 ± 6.7 | 135.9 ± 8.6 |
Unless otherwise indicated, all measurements were acquired using a K-gluconate internal recording solution from 4–7 mice. Number of cells are in parentheses. Values are mean ± SE. Cm: cell membrane capacitance; Rm: input resistance; CsMe: cesium methanesulfonate internal recording solution.