Table 1. Number of Genes in Pathogens Related to Resistance to Class I Lantibiotics.
| bacterial strain | C. difficile VPI10463 | E. faecium ATCC700221 | S. aureus USA300 | S. epidermidis SK135 | L. monocytogenes 10403s | mechanism of resistance |
|---|---|---|---|---|---|---|
| nisin A MIC (μM) | 2.67 | 1.48 | 2.67 | 2.67 | 2.67 | |
| median MIC (μM) | 4.44 | 13.3 | >13.3 | >13.3 | >13.3 | |
| cell wall biosynthesis | ||||||
| complete dltABCD | 1 | 1 | 1 | 1 | 1 | changing cell wall charge |
| efflux pump | ||||||
| complete lanFEG | 1 | 0 | 1 | 0 | 0 | lantibiotic efflux |
| complete bceAB | 0 | 1 | 1 | 1 | 1 | bacitracin efflux |
| others | ||||||
| telA | 1 | 1 | 1 | 1 | 1 | unknown |
| mprF | 0 | 2 | 1 | 1 | 1 | changing cell membrane charge |
| nsr | 0 | 0 | 0 | 0 | 0 | lantibiotic protease |
| lanI | 0 | 0 | 0 | 0 | 0 | lantibiotic sequestration |