Table 2. Number of Genes in Human Gut Commensals Related to Resistance of Nisin-like Lantibiotics.
| bacterial strain | A. hadrus MSK.14.23 | D. formicigenerans MSK.17.61 | B. obeum MSK.18.40 | Coprococcus eutactus MSK.18.32 | B. luti MSK.20.18 | F. fissicatena MSK.9.3 | C. comes MSK.11.23 | E. ramosum MSK.23.96 | mechanism of resistance |
|---|---|---|---|---|---|---|---|---|---|
| nisin A MIC (μM) | 0.0110 | 0.0110 | 0.0110 | 0.0110 | 0.0329 | 0.0329 | 0.296 | 0.889 | |
| median MIC (μM) | 0.0329 | 0.0329 | 0.0988 | 0.0988 | 0.0988 | 0.0988 | 0.296 | >2.67 | |
| cell wall biosynthesis | |||||||||
| complete dltABCD | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | changing cell wall charge |
| efflux pump | |||||||||
| complete lanFEG | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | lantibiotic efflux |
| complete bceAB | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 2 | bacitracin efflux |
| others | |||||||||
| telA | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 0 | unknown |
| mprF | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | changing cell membrane charge |
| nsr | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | lantibiotic protease |
| lanI | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | lantibiotic sequestration |