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Scheme 3. Addition of Carboxylic
Acids to Tetrasubstituted gem-Difluoroalkenes.
Unless specified otherwise,
reactions
were carried out using 0.2 mmol of 1 for 48 h. Isolated
yields. Condition A: 10 equiv of carboxylic acid at 75 °C. Condition
B: 3.0 equiv of carboxylic acid at 150 °C.