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. 2024 Feb 1;26(6):1261–1264. doi: 10.1021/acs.orglett.4c00095

Scheme 3. Addition of Carboxylic Acids to Tetrasubstituted gem-Difluoroalkenes.

Scheme 3

Unless specified otherwise, reactions were carried out using 0.2 mmol of 1 for 48 h. Isolated yields. Condition A: 10 equiv of carboxylic acid at 75 °C. Condition B: 3.0 equiv of carboxylic acid at 150 °C.