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. 2024 Mar;105(3):131–143. doi: 10.1124/molpharm.123.000788

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Fig. 3. — CerS2 expression regulates sphingolipid acyl-chain length in the kidney. Relative mRNA expression of (A) CerS isoforms, (B) ceramide-generating enzymes, and (C) ceramide-degrading enzymes were analyzed using real-time reverse-transcription polymerase chain reaction. (D–I) Sphingolipid levels were assessed using liquid chromatography tandem mass spectrometry (LC-MS/MS) and normalized to protein [(D) ceramides, (E) dihydroceramides, (F) SMs, (G) hexosylceramides (HexCer), (H) lactosylceramides (LactCer), and (I) sphingoid bases]. (J) Table detailing CerS expression and most abundant sphingolipid species in the kidney. (K) Donut plots depicting CerS expression (left panel) and CerS contribution to ceramide species (right panel).