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Comparison of the activities of wild type and mutant LdTop2 proteins
| Mutants | Aminoacids deleted | ATPase Activity | DNA-binding | Cleavage activity |
|---|---|---|---|---|
| LdΔNΔC (40 kDa) | 429 from N-terminus 451 from C-terminus (residues 430–785) | − | − | − |
| Core (70 kDa) | 429 from N-terminus 178 from C-terminus (residues 430–1058) | − | + | + |
| LdΔN429 (89 kDa) | 429 from N-terminus (residues 430–1236) | − | + | + |
| LdΔC1058 (116 kDa) | 178 from C-terminus (residues 1–1058) | + | + | + |
| LdTOP2 (wild type) | 1236 amino acid | + | + | + |
