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Metal chelation inhibits RNA binding by CPEB. (A) Wild-type CPEB was incubated overnight with various amounts of 1,10-phenanthroline or 4,7-phenanthroline (100 to 500 μM) and then used in a gel shift with radiolabeled B4 RNA. (B) Quantification of the binding data, plotted as percent RNA bound versus concentration of phenanthroline. Closed bars, reaction mixtures containing 1,10-phenanthroline; open bars, reaction mixtures containing 4,7-phenanthroline.
