Table 5.
Multiple linear regression analysis of the association of macular VD and WMH volume including adjusting factors
| Variables | Coefficient | t | Significance | Beta |
|---|---|---|---|---|
| Age | 0.05 | 4.83 | < 0.001* | 0.37 |
| Sex | 0.06 | 0.41 | 0.685 | 0.03 |
| Syndromic diagnosis | 0.20 | 1.40 | 0.163 | 0.10 |
| Hypertension | 0.34 | 2.28 | 0.024 | 0.16 |
| Diabetes mellitus | 0.60 | 2.09 | 0.038 | 0.14 |
| Dyslipidemia | − 0.06 | 0.44 | 0.660 | − 0.03 |
| Heart disease | 0.09 | 0.38 | 0.702 | 0.03 |
| Respiratory disease | 0.38 | 1.75 | 0.082 | 0.12 |
| Smoking | − 0.03 | 0.20 | 0.845 | − 0.01 |
| VD nasal | − 0.04 | 1.97 | 0.051 | − 0.17 |
| VD temporal | 0.05 | 1.93 | 0.056 | 0.19 |
| VD superior | − 0.01 | 0.58 | 0.563 | − 0.05 |
| VD inferior | 0.01 | 0.47 | 0.640 | 0.03 |
Including age, sex, syndromic diagnosis, hypertension, diabetes mellitus, dyslipidemia, heart disease, respiratory disease, and smoking as adjusting factors
A log transformation was applied to WMH volume measures
Abbreviations: VD Vessel density, WMH White matter hyperintensities
*Significance was set up at p < 0.0125