Figure 1.

Distinct multi-omic expression profiles identified tuberculosis regardless the glycemic status

Right panel. A hierarchical cluster analysis (Ward method with 100 × bootstrap) was employed to test the overall expression of plasma cytokines, gene expression and urinary eicosanoids in the study population. Dendrograms represent Canberra distance. Left panel. Differential expression analysis was used to calculate the fold-changes and show differences in biomarkers levels for each clinical group (TB, TB-DM, and DM) versus control. Differences that reached statistical significance after adjustment for multiple comparisons (adjusted p < 0.05) are represented in colored bars.