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. 2024 Feb 19;16(1):2315640. doi: 10.1080/19420862.2024.2315640

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© 2024 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 7. — VHH location induce different pharmacokinetic profiles of bispecific EGFR x NKp30 NKCEs. Mouse plasma concentrations of bispecific eff+ NKCEs and cetuximab were measured over time after single intravenous administration of 3 mg/kg of the indicated molecules. Mean concentrations ± SEM of 3 specimen per sample are shown for cetuximab (black), HC-bvVHH1-bvhu225_IgG eff+ (ocher), LC-bvVHH1-N-term-bvhu225_IgG eff+ (pink) and LC-bvVHH1-C-term-bvhu225_IgG eff+ (purple) as determined by ELISA.