Table 5.

PK properties of eff+ bivalent NKp30 × EGFR IgG-based NKCEs with differently located VHH in C57BL/6N mice. The percentage of extrapolated area under the curve (AUCinf) was generally high for total antibody and therefore AUCinf as well as clearance (CL) and volume of distribution at steady state (Vss) calculated using AUCinf should be considered cautiously. Half-life (t_1/2) was derived from the 3 terminal data points.

	t1/2 [h]	Cmax [ng/mL]	AUCinf [h*ng/mL]	CL [mL/h/kg]	Vss [mL/kg]
HC-bv-VHH1-C-term-bvhu225_IgG eff+	206	37800	8390000	0.357	123
LC-bv-VHH1-C-term-bvhu225_IgG eff+	239	30500	7260000	0.413	152
LC-bv-VHH1-N-term-bvhu225_IgG eff+	214	44500	6390000	0.470	141
cetuximab	281	38400	11700000	0.257	112